Hesperidin and neohesperidin dihydrochalcone on different experimental models of induced gastric ulcer

Hesperidin and neohesperidin dihydrochalcone show a marked capacity to reduce the nicer index in cold-restraint induced ulcer in a clear dose-related manner, The amount of gastric mucus and total protein were not modified, but there was a significant increase In hexosamine content, When the acute ulcer was induced by absolute ethanol RESP was inactive, These results suggest that mucus is not involved in the antiulcer activity, In both experimental models, HESP and NEOHESP did not produce an increase in total PGE(2), suggesting that this mechanism of action is not involved in the antiulcer activity of these compounds.