Three New 9,11-Secosterols from the Formosan Soft Coral Sinularia leptoclados

被引：20

作者：

Cheng, Shi-Yie ^{[2
]}

Chen, Hwa-Pyng ^{[2
]}

Wang, Shang-Kwei ^{[1
]}

Duh, Chang-Yih ^{[2
,3
]}

机构：

[1] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2011年 / 84卷 / 06期

关键词：

SPONGE SPONGIA-OFFICINALIS; GERSEMIA-FRUTICOSA; INDIAN-OCEAN; STEROIDS; STEREOCHEMISTRY; SECOSTEROIDS; DITERPENOIDS; METABOLITES;

D O I：

10.1246/bcsj.20110046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical investigations of the Formosan soft coral Sinularia leptoclados resulted in the characterization of three new 9,11-secosterols, designated as leptosterols A-C (1-3), and six known 9,11-secosterols 5-10. Additionally, a cyclized 9,11-secosterol enol-ether 4 was obtained by allowing 5 to stand in CDCl3 overnight during NMR experiments. The structures of 1-4 were elucidated through extensive spectroscopic analyses. The cytotoxicity against selected cancer cells and antiviral activity against human cytomegalovirus (HCMV) of 1-10 were evaluated in vitro.

引用

页码：648 / 652

页数：5

共 25 条

[1] Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the mediterranean ascidian Aplidium conicum [J].

Aiello, A ;

Esposito, G ;

Fattorusso, E ;

Iuvone, T ;

Luciano, P ;

Menna, M .

STEROIDS, 2003, 68 (09) :719-723

[2] Steroids from sponges: Recent reports [J].

Aiello, A ;

Fattorusso, E ;

Menna, M .

STEROIDS, 1999, 64 (10) :687-714

[3] New 9,11-secosterols from gorgonia Subergorgia suberosa of the Indian Ocean [J].

Aknin, M ;

Costantino, V ;

Mangoni, A ;

Fattorusso, E ;

Gaydou, EM .

STEROIDS, 1998, 63 (11) :575-578

[4] Rare aromadendrane diterpenoids from a new soft coral species of Sinularia genus of the Indian Ocean [J].

Anjaneyulu, ASR ;

Krishnamurthy, MVR ;

Rao, GV .

TETRAHEDRON, 1997, 53 (27) :9301-9312

[5] MINOR AND TRACE STEROLS IN MARINE-INVERTEBRATES .41. STRUCTURE AND STEREOCHEMISTRY OF NATURALLY-OCCURRING 9,11-SECO STEROLS [J].

BONINI, C ;

COOPER, CB ;

KAZLAUSKAS, R ;

WELLS, RJ ;

DJERASSI, C .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (12) :2108-2111

[6] HERBASTEROL, AN ICHTHYOTOXIC 9,11-SECOSTEROL FROM THE SPONGE DYSIDEA-HERBACEA [J].

CAPON, RJ ;

FAULKNER, DJ .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (24) :4771-4773

[7] Anti-inflammatory cembranolides from the soft coral Lobophytum durum [J].

Cheng, Shi-Yie ;

Wen, Zhi-Hong ;

Wang, Shang-Kwei ;

Chiou, Shu-Fen ;

Hsu, Chi-Hsin ;

Dai, Chang-Feng ;

Duh, Chang-Yih .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (11) :3763-3769

[8] EURYSPONGIOLS - 10 NEW HIGHLY HYDROXYLATED 9,11-SECOSTEROIDS WITH ANTIHISTAMINIC ACTIVITY FROM THE SPONGE EURYSPONGIA SP - STEREOCHEMISTRY AND REDUCTION [J].

DOPESO, J ;

QUINOA, E ;

RIGUERA, R ;

DEBITUS, C ;

BERGQUIST, PR .

TETRAHEDRON, 1994, 50 (12) :3813-3828

[9] Diterpenoids, norditerpenoids, and secosteroids from the Formosan soft coral Cespitularia hypotentaculata [J].

Duh, Chang-Yih ;

Li, Chia-Hua ;

Wang, Shang-Kwei ;

Dai, Chang-Feng .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08) :1188-1192

[10]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

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