Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the comirnaty COVID-19 vaccine in nursing home residents

被引：23

作者：

Sanchez-Sendra, Beatriz ^{[1
]}

Albert, Eliseo ^{[2
]}

Zulaica, Joao ^{[1
]}

Torres, Ignacio ^{[2
]}

Gimenez, Estela ^{[2
]}

Botija, Pilar ^{[3
]}

Jose Beltran, Maria ^{[4
]}

Rodado, Celia ^{[5
]}

Geller, Ron ^{[1
]}

Navarro, David ^{[2
,6
]}

机构：

[1] Univ Valencia, CSIC, Inst Integrat Syst Biol I2SysBio, Valencia 46980, Spain

[2] Clin Univ Hosp, INCLIVA Hlth Res Inst, Microbiol Serv, Valencia, Spain

[3] Hosp Clin Univ Valencia, Dept Salud Clin Malvarrosa, Direcc Atenc Primaria, Valencia, Spain

[4] Hosp Clin Univ Valencia, Dept Salud Clin Malvarrosa, Direcc Enfermeria, Valencia, Spain

[5] Comis Dept Control Residencias, Dept Salud Valencia Clin Malvarrosa, Valencia, Spain

[6] Univ Valencia, Dept Microbiol, Sch Med, Av Blasco Ibanez 17, Valencia 46010, Spain

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

D O I：

10.1038/s41598-022-07849-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunosenescence may impact the functionality and breadth of vaccine-elicited humoral immune responses. The ability of sera to neutralize the SARS-CoV-2 spike protein (S) from Beta, Gamma, Delta, and Epsilon variants of concern (VOCs) relative to the ancestral Wuhan-Hu-1 strain was compared in Comirnaty COVID-19-vaccinated elderly nursing home residents, either SARS-CoV-2 naive (n=22) or experienced (n=8), or SARS-CoV-2 naive younger individuals (n=18) and non-vaccinated individuals who recovered from severe COVID-19 (n=19). In all groups, except that including SARS-CoV-2-experienced nursing home residents, some participants lacked NtAb against one or more VOCs, mainly the Beta variant (15-20%). Serum NtAb titers were lowest against the Beta variant followed by Gamma, Delta and Epsilon variants. Overall, fold change reduction in NtAb titers relative to the ancestral strain was greatest for the Beta variant (6.7-19.4) followed by Gamma (4.8-16.0), Epsilon (2.9-13.4), and Delta (3.5-6.5) variants, although subtle differences were observed for Beta, Epsilon and Delta variants across comparison groups. In summary, older age, frailty, and concurrence of co-morbidities had no major impact on the serum NtAb activity profile against SARS-CoV-2 VOCs.

引用

页数：8

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