Amino acid induced self-assembled vesicles of choline oleate: pH responsive nano-carriers for targeted and localized delivery of doxorubicin for breast cancer

Traditionally administered chemotherapeutic drugs via oral or parental routes for the treatment of breast cancer often results in serious systemic side effects. To ameliorate this, efforts have been made for the advanced drug carrier system that precisely releases the drug at the targeted site and increases the therapeutic efficiency with reduced side effects. The advanced nano-carrier system with high permeability can penetrate or absorbed through the mammary fat layers of the breast and deliver the drug judiciously. In our efforts towards addressing the proof of concept of drug delivery for the treatment of breast cancer, herein we had designed the pH-responsive vesicles with high permeability within the mammary fat layers. The vesicles were designed as a result of synergistic interaction between the surface active ionic liquid (SAIL), choline oleate ([Ch][Ol]) and glutamic acid (GA). [Ch][Ol] have the ability to permeate through the mammary fat layers whereas GA is a known a-amino acid and chemotherapeutic agent that can modulate the cancer cell development, proliferation and metastatic through regulating the cell signalling pathways. As such designed vesicles show good biocompatibility and pH-responsive behaviour and are formed through structurally transitioned from the micelles. Various state of the art analytical techniques were used to characterized the formation of the vesicles. These vesicles were explored for the encapsulation as well as sustained and targeted release of anticancer drug, doxorubicin. The proposed study would pave the way for the preparation of biocompatible and stimuli responsive drug carrier for targeted and localized delivery of anticancer drug to treat the breast cancer. (C) 2022 Elsevier B.V. All rights reserved.