Total synthesis of two natural phenanthrenes: confusarin and a regioisomer

被引：22

作者：

Radix, Sylvie ^{[1
,2
,3
]}

Barret, Roland ^{[1
,2
,3
]}

机构：

[1] Univ Lyon, F-69003 Lyon, France

[2] Univ Lyon 1, ISPB, F-69373 Lyon 08, France

[3] INSERM, U836, IFR62, F-69373 Lyon 08, France

来源：

TETRAHEDRON | 2007年 / 63卷 / 50期

关键词：

total synthesis; Wittig reaction; radical cyclization; Stilbenes; aromatics; phenanthrenes; 2,4,8-trimethoxyphenanthrene-3,7-diol; confusarin;

D O I：

10.1016/j.tet.2007.09.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds were synthesized by radical cyclization of the corresponding stilbenes intermediates. The latter ones arose from a Wittig reaction in a stereoselective manner (Z isomer is either the only one or the major one). Confusarin (1) was prepared in 13 steps from gallic acid. Its regioisomer (2) was obtained in five steps from syringaldehyde. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：12379 / 12387

页数：9

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