Chemoselective Reduction of Isatin-Derived Electron-Deficient Alkenes Using Alkylphosphanes as Reduction Reagents

被引：54
作者：
Cao, Shu-Hua [2 ,3 ]
Zhang, Xiu-Chun [2 ,3 ]
Wei, Yin [1 ]
Shi, Min [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[3] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Reduction; Alkenes; Chemoselectivity; Phosphanes; CATALYTIC ASYMMETRIC-SYNTHESIS; STAUDINGER REACTIONS; ALKYL PHOSPHINES;
D O I：
10.1002/ejoc.201100017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Under mild reaction conditions, the C=C double bond in isatin-derived electron-deficient alkenes has been exclusively reduced in the presence of alkylphosphanes and water to afford the corresponding reduction products in good to excellent yields. A plausible mechanism is proposed on the basis of deuterium-labeling experiments.
引用
收藏
页码：2668 / 2672
页数：5
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