Chemoselective Reduction of Isatin-Derived Electron-Deficient Alkenes Using Alkylphosphanes as Reduction Reagents

被引：56

作者：

Cao, Shu-Hua ^{[2
,3
]}

Zhang, Xiu-Chun ^{[2
,3
]}

Wei, Yin ^{[1
]}

Shi, Min ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Reduction; Alkenes; Chemoselectivity; Phosphanes; CATALYTIC ASYMMETRIC-SYNTHESIS; STAUDINGER REACTIONS; ALKYL PHOSPHINES;

D O I：

10.1002/ejoc.201100017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under mild reaction conditions, the C=C double bond in isatin-derived electron-deficient alkenes has been exclusively reduced in the presence of alkylphosphanes and water to afford the corresponding reduction products in good to excellent yields. A plausible mechanism is proposed on the basis of deuterium-labeling experiments.

引用

收藏

页码：2668 / 2672

页数：5

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