In vitro and in vivo biocompatibility of graded hydroxyapatite-zirconia composite bioceramic

被引：41

作者：

Quan, Renfu ^{[1
,2
]}

Yang, Disheng ^{[1
]}

Wu, Xiaochun ^{[3
]}

Wang, Hongbin ^{[3
]}

Miao, Xudong ^{[3
]}

Li, Wei ^{[3
]}

机构：

[1] Zhejiang Univ, Dept Orthopaed, Affiliated Hosp 2, Hangzhou 310009, Peoples R China

[2] Zhejiang Univ, Xiaoshan Tradit Chinese Med Hosp, Dept Orthopaed, Hangzhou 311201, Peoples R China

[3] Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200072, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 01期

关键词：

D O I：

10.1007/s10856-006-0025-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To obtain bioceramics with good osteoinductive ability and mechanical strength, graded hydroxyapatite-zirconia (HA-ZrO2) composite bioceramics were prepared in this work. The biocompatibility of the bioceramics was investigated in vitro based on acute toxicity and cytotoxicity tests and hemolysis assay. Results showed the studied graded HA-ZrO2 had little toxicity to mouse and L929 mouse fibroblasts. Also, hemolysis assay indicated a good blood compatibility of the bioceramics. Based on the results of in vitro tests, animal experiments were performed on white New Zealand rabbits by implantation into hip muscles and femur. It was found that the graded HA-ZrO2 composite bioceramics exhibited superior osteoinductive ability, which may be a promising bioceramics implant.

引用

页码：183 / 187

页数：5

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