Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms

被引：129

作者：

Kopelman, NM ^{[1
]}

Lancet, D ^{[1
]}

Yanai, I ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

NATURE GENETICS | 2005年 / 37卷 / 06期

关键词：

D O I：

10.1038/ng1575

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene duplication and alternative splicing are distinct evolutionary mechanisms that provide the raw material for new biological functions. We explored their relationships in human and mouse and found an inverse correlation between the size of a gene's family and its use of alternatively spliced isoforms. A cross-organism analysis suggests that selection for genome-wide genic proliferation might be interchangeably met by either evolutionary mechanism.

引用

页码：588 / 589

页数：2

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