Supramolecular hybrids of carbon dots with doxorubicin: synthesis, stability and cellular trafficking

被引：62
作者：
Sun, Tingting [1 ,2 ]
Zheng, Min [3 ]
Xie, Zhigang [1 ]
Jinga, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Changchun Univ Technol, Adv Inst Mat Sci, Chem & Life Sci Sch, 2055 Yanan St, Changchun 130012, Jilin, Peoples R China
来源：
MATERIALS CHEMISTRY FRONTIERS | 2017年 / 1卷 / 02期
基金：
中国国家自然科学基金;
关键词：
GRAPHENE QUANTUM DOTS; VIVO CANCER-THERAPY; DRUG-DELIVERY; IN-VIVO; BIOMEDICAL APPLICATIONS; NANODOTS SYNTHESIS; TARGETED DELIVERY; NANOPARTICLES; OXIDE; WATER;
D O I：
10.1039/c6qm00042h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Supramolecular hybrids of carbon dots (CDs) and doxorubicin (Dox) were successfully prepared via p-p stacking and electrostatic interactions. The hybrids were characterized by the changes in size, morphology and zeta potential, and further validated by the absorption and photoluminescence spectra. A binding constant of 63 L g(-1) between CDs and Dox was calculated from the Stern-Volmer plot. The hybrids between CDs and Dox (CDs-Dox) showed pH-dependent drug loading and release behaviors in aqueous solution. The poor stability of CDs-Dox in fetal bovine serum (FBS) solution led to the rapid separation of Dox and CDs, facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy (CLSM). After being coated with polydopamine (CDs-Dox@PDA), the stability of the hybrids in cell culture media was enhanced, as supported by the slow release of Dox in living cells. This work highlights the potential of using CDs to synthesize functional nanoparticles through supramolecular interactions.
引用
收藏
页码：354 / 360
页数：7
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