Occurrence of Anaemia in the First Year of Inflammatory Bowel Disease in a European Population-based Inception Cohort-An ECCO-EpiCom Study

被引：27

作者：

Burisch, Johan ^{[1
]}

Vegh, Zsuzsanna ^{[2
]}

Katsanos, Konstantinnos H. ^{[3
,4
]}

Christodoulou, Dimitrios K. ^{[3
,4
]}

Lazar, Daniela ^{[5
]}

Goldis, Adrian ^{[5
]}

O'Morain, Colm ^{[6
]}

Fernandez, Alberto ^{[7
]}

Pereira, Santos ^{[8
]}

Myers, Sally ^{[9
]}

Sebastian, Shaji ^{[9
]}

Pedersen, Natalia ^{[10
]}

Olse, Jongero ^{[11
]}

Nielsen, Kari Rubek ^{[11
]}

Schwartz, Doron ^{[12
,13
]}

Odes, Selwyn ^{[12
,13
]}

Almer, Sven ^{[14
,15
]}

Halfvarson, Jonas ^{[16
]}

Turk, Niksa ^{[17
]}

Cukovic-Cavka, Silvja ^{[17
]}

Nikulina, Inna ^{[18
]}

Belousova, Elena ^{[18
]}

Duricova, Dana ^{[19
]}

Bortlik, Martin ^{[19
,20
]}

Shonova, Olga ^{[21
]}

Salupere, Riina ^{[22
]}

Barros, Louisa ^{[23
]}

Magro, Fernando ^{[24
,25
,26
]}

Jonaitis, Laimas ^{[27
]}

Kupcinskas, Limas ^{[27
]}

Turcan, Svetlana ^{[28
]}

Kaimakliotis, Ioannis

Ladefoged, Karin ^{[29
]}

Kudsk, Karen ^{[30
]}

Andersen, Vibeke ^{[30
,31
,32
]}

Vind, Ida ^{[33
]}

Thorsgaard, Niels ^{[34
]}

Oksanen, Pia ^{[35
]}

Collin, Pekka ^{[35
]}

Dal Piaz, Giulia ^{[36
,37
]}

Santini, Alessia ^{[37
,38
]}

Niewiadomski, Ola ^{[39
]}

Bell, Sally ^{[39
]}

Moum, Bjorn ^{[40
]}

Arebi, Naila ^{[41
]}

Kjeldsen, Jens ^{[42
]}

Carlsen, Katrine ^{[43
]}

Langholz, Ebbe ^{[44
]}

Lakatos, Peter Laszlo ^{[2
]}

Munkholm, Pia ^{[1
]}

机构：

[1] North Zealand Univ Hosp, Dept Gastroenterol, Frederikssundvej 30, DK-3600 Frederikssund, Denmark

[2] Semmelweis Univ, Dept Med 1, Budapest, Hungary

[3] Univ Hosp, Div Internal Med 1, Ioannina, Greece

[4] Univ Hosp, Hepato Gastroenterol Unit, Ioannina, Greece

[5] Univ Med Victor Babes, Clin Gastroenterol, Timisoara, Romania

[6] TCD, Adelaide & Meath Hosp, Dept Gastroenterol, Dublin, Ireland

[7] POVISA Hosp, Dept Gastroenterol, Vigo, Spain

[8] Inst Invest Sanitaria Galicia, Dept Gastroenterol, Estrut Org Xestion Integrada Vigo, Vigo, Spain

[9] Hull & East Yorkshire NHS Trust, IBD Unit, Kingston Upon Hull, N Humberside, England

[10] Slagelse Hosp, Gastroenterol Dept, Slagelse, Denmark

[11] Natl Hosp Faroe Islands, Med Dept, Torshavn, Denmark

[12] Soroka Med Ctr, Dept Gastroenterol Hepatol, Beer Sheva, Israel

[13] Ben Gurion Univ Negev, Beer Sheva, Israel

[14] Karolinska Inst, Dept Med, Stockholm, Sweden

[15] Karolinska Univ Hosp, Ctr Digest Dis, Stockholm, Sweden

[16] Orebro Univ, Fac Med & Hlth, Dept Gastroenterol, Orebro, Sweden

[17] Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Zagreb, Croatia

[18] Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia

[19] Charles Univ Prague, IBD Clin & Res Ctr, ISCARE, Prague, Czech Republic

[20] Charles Univ Prague, Med Fac 1, Inst Pharmacol, Prague, Czech Republic

[21] Hosp Ceske Budejovice, Gastroenterol Dept, Ceske Budejovice, Czech Republic

[22] Tartu Univ Hosp, Div Gastroenterol, Tartu, Estonia

[23] Hosp Vale de Sousa, Dept Med, Oporto, Portugal

[24] Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal

[25] Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal

[26] Univ Porto, Inst Mol & Cellular Biol, Oporto, Portugal

[27] Lithuanian Univ Hlth Sci, Inst Digest Dis, Kaunas, Lithuania

[28] State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova

[29] Dronning Ingrids Hosp, Med Dept, Nuuk, Greenland

[30] Univ Southern Denmark, Inst Mol Med, Odense, Denmark

[31] Hosp Southern Jutland, Lab Ctr, Aabenraa, Denmark

[32] Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark

[33] Univ Copenhagen, Hosp Hvidovre, Med Div, Gastrounit, Hvidovre, Denmark

[34] Herning Cent Hosp, Dept Med, Herning, Denmark

[35] Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland

[36] Osped Morgagni Pierantoni, Dipartimento Med Specialist Gastroenterolo & Endo, Forli, Italy

[37] EpiCom Northern Italy Ctr based Crema Cremona Fir, Florence, Italy

[38] Careggi Hosp, Gastroenterol Unit, Florence, Italy

[39] St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia

[40] Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway

[41] Imperial Coll London, St Marks Hosp, London, England

[42] Odense Univ Hosp, Dept Med Gastroenterol, Odense, Denmark

[43] Hvidovre Univ Hosp, Dept Pediat, Hvidovre, Denmark

[44] Herlev Univ Hosp, Dept Gastroenterol, Herlev, Denmark

[45] Ctr Qual, Middelfart, Denmark

[46] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark

来源：

JOURNAL OF CROHNS & COLITIS | 2017年 / 11卷 / 10期

关键词：

anaemia; inflammatory bowel disease; prevalence; QUALITY-OF-LIFE; IRON-DEFICIENCY; FOLLOW-UP; CROHNS-DISEASE; PREVALENCE; MANAGEMENT; DIAGNOSIS; CONSENSUS; SURGERY; COLITIS;

D O I：

10.1093/ecco-jcc/jjx077

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and aims: Anaemia is an important complication of inflammatory bowel disease [IBD]. The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis, in a European prospective population-based inception cohort. Methods: Newly diagnosed IBD patients were included and followed prospectively for 1 year in 29 European and one Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization criteria. Results: A total of 1871 patients (Crohn's disease [CD]: 686, 88%; ulcerative colitis [UC]: 1,021, 87%; IBD unclassified [IBDU] 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and, overall, 49% of CD and 39% of UC patients experienced at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed. Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

引用

页码：1213 / 1222

页数：10

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