3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

被引：39

作者：

Dimmock, JR

Das, U

Gul, HI

Kawase, M

Sakagami, H

Baráth, Z

Ocsovsky, I

Molnár, J

机构：

[1] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7N 5C9, Canada

[2] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

[3] Univ Szeged, Albert Szent Gyorgyi Med Ctr, Inst Med Microbiol & Immunobiol, H-6720 Szeged, Hungary

[4] Univ Szeged, Albert Szent Gyorgyi Med Ctr, Dept Biochem, H-6720 Szeged, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.bmcl.2005.01.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance. © 2005 Elsevier Ltd. All rights reserved.

引用

页码：1633 / 1636

页数：4

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