Angioimmunoblastic T-Cell lymphoma -: Clinical and laboratory features at diagnosis in 77 patients

被引:99
作者
Lachenal, Florence [1 ]
Berger, Francoise
Ghesquieres, Herve
Biron, Pierre
Hot, Arnaud
Callet-Bauchu, Evelyne
Chassagne, Catherine
Coiffier, Bertrand
Durieu, Isabelle
Rousset, Hugues
Salles, Gilles
机构
[1] Ctr Hosp Lyon Sud, Dept Internal Med, F-69495 Pierre Benite, France
[2] Ctr Hosp Lyon Sud, Dept Pathol, F-69495 Pierre Benite, France
[3] Ctr Hosp Lyon Sud, Dept Cytogenet & Mol Biol, F-69495 Pierre Benite, France
[4] Ctr Hosp Lyon Sud, Dept Hematol, F-69495 Pierre Benite, France
[5] Hosp Edouard Herriot, Dept Internal Med, Lyon, France
[6] Ctr Leon Berard, Dept Hematol, F-69373 Lyon, France
[7] Ctr Leon Berard, Dept Pathol, F-69373 Lyon, France
[8] Univ Lyon 1, Villeurbanne, France
关键词
NON-HODGKINS-LYMPHOMA; ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOPROLIFERATIVE DISORDERS; CUTANEOUS INVOLVEMENT; HELPER-CELLS; CHROMOSOME-ABNORMALITIES; CYCLOSPORINE-A; DYSPROTEINEMIA; EXPRESSION; CLASSIFICATION;
D O I
10.1097/MD.0b013e3181573059
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We retrospectively analyzed 77 patients with pathologically diagnosed angioimmunoblastic T-cell lymphoma from a single city. There were 43 men and 34 women; the median age was 64.5 years (range, 30-91 yr). Average time between first symptoms of the disease and diagnosis was 3.6 months. At diagnosis, peripheral nodes were present in all but 1 patient, and were generalized in 90% of cases. Constitutional symptoms were reported in 77% of cases and spleen enlargement in 51%. A cutaneous eruption-morbilliform, urticarial, or more polymorphic was present in 45% of patients; in one-third of them, the eruption occurred after drug administration. Other clinical manifestations included pleuritis (22%); arthralgia or arthritis (17%); ear, nose, and throat involvement (14%); central or peripheral neurologic manifestations (10%); and ascites (5%). Most patients presented with advanced disease at diagnosis (bone marrow involvement in 60% of cases). The main laboratory abnormalities were elevated lactate dehydrogenase levels (71%), inflammatory syndrome (67%), hypergammaglobulinemia (50%), anemia (51%), and lymphopenia (52%). Auto- or disimmune manifestations were reported in one-third of patients: autommume hemolytic anemia was present at diagnosis in 19% of patients and thrombocytopenic purpura in 7%. Documented vasculitis was described in 12% of cases. Clonality was analyzed in lymph nodes in 47 patients: T-cell and B-cell clones were found in 45 (96%) and 20 (45%) patients, respectively. Chromosomal abnormalities were identified in 62% of cases: trisomies 3, 5, 18, 19, additional X chromosome, and deletion of chromosome 7 were the most common abnormalities. The current study underlines the diversity of presenting manifestations of angioinummoblastic T-cell lymphoma.
引用
收藏
页码:282 / 292
页数:11
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