Ameliorating effects and mechanisms of chronic electroacupuncture at ST36 in a rodent model of dyspepsia induced by cisplatin

被引：24
作者：
Liu, Yi [1 ,2 ,3 ]
Zhang, Sunjuan [1 ,3 ,4 ]
Ye, Feng [1 ,2 ,3 ]
Yin, Jieyun [3 ]
Li, Shiying [1 ,3 ]
Chen, Jiande D. Z. [1 ,3 ]
机构：
[1] Vet Res & Educ Fdn, VA Med Ctr, Oklahoma City, OK USA
[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
[3] Johns Hopkins Ctr Neurogastroenterol, Div Gastroenterol & Hepatol, Baltimore, MD USA
[4] Tianjin 254 Hosp, Dept Gastroenterol, Tianjin, Peoples R China
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2019年 / 31卷 / 01期
基金：
美国国家科学基金会;
关键词：
autonomic functions; chemotherapy-associated dyspeptic syndrome; electroacupuncture; gastric slow wave; gastrointestinal motility; CHEMOTHERAPY-INDUCED NAUSEA; INCREASED PLASMA GHRELIN; HEART-RATE-VARIABILITY; SATIETY SEQUENCE BSS; DORSAL VAGAL COMPLEX; ELECTRICAL-STIMULATION; GASTRIC-MOTILITY; TREATMENT PREVENTS; INDUCED IMPAIRMENT; IMPROVES;
D O I：
10.1111/nmo.13474
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background Chemotherapy-associated dyspepsia syndrome (CADS) is among the most intensive side effects and critical concerns for patients with cancer. To investigate the effects and mechanisms of chronic electroacupuncture (EA) at ST36 on chemotherapy-associated dyspeptic symptoms (CADS) in rats. Methods Cisplatin (8 mg/kg, ip) was given once to establish CADS model. EA or sham-EA treatment was then performed one hour daily for 21 days. Key Results (a) EA treatment decreased kaolin intake within 24 hours (1.67 +/- 0.23 g vs 2.36 +/- 0.37 g in sham-EA, P < 0.05); EA increased food intake (9.43 +/- 2.28 vs 4.32 +/- 1.26 in sham-EA, P < 0.05) and cisplatin-induced reduction of body weight (426.38 +/- 13.25 vs 407.92 +/- 13.26 in sham-EA, P = 0.05). (b) The incidence of normal behavioral satiety sequence (53%) in EA group was greater than that in sham-EA (32%) group (X-2 = 17.68, P < 0.01). (c) EA increased the percentage of normal gastric slow waves (82.6 +/- 5.98 vs 22.8 +/- 1.90 in sham-EA, P < 0.05). (d) EA normalized cisplatin delayed gastric emptying (71.3% +/- 6.8% vs 44.6% +/- 11.2% in control, P < 0.05). (e) EA decreased ratio of heart rate variability (0.30 +/- 0.03 vs 0.56 +/- 0.05 in sham-EA, P < 0.05). (f) EA decreased fasting ghrelin, glucagon-like peptide-1 and peptide YY (P < 0.01 vs sham-EA for all). Conclusions and Inferences Chronic EA ameliorates dyspepsia symptom and improves gastric dysmotility induced by Cisplatin, mediated via the vagal and gastrointestinal hormonal mechanisms.
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页数：9
相关论文
共 59 条
[1]   A preliminary discussion on rules of clinical acupoint selection of acupuncture for the treatment of chemotherapy-induced nausea and vomiting [J].
An Qi ;
Chen Bo ;
Guo Yi ;
Pan Xing-fang ;
Guo Yong-ming .
WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION, 2015, 25 (02) :39-+
[2]   Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting [J].
Angeli, Timothy R. ;
Cheng, Leo K. ;
Du, Peng ;
Wang, Tim Hsu-Han ;
Bernard, Cheryl E. ;
Vannucchi, Maria-Giuliana ;
Faussone-Pellegrini, Maria Simonetta ;
Lahr, Christopher ;
Vather, Ryash ;
Windsor, John A. ;
Farrugia, Gianrico ;
Abell, Thomas L. ;
O'Grady, Gregory .
GASTROENTEROLOGY, 2015, 149 (01) :56-+
[3]   CHOLECYSTOKININ ELICITS COMPLETE BEHAVIORAL SEQUENCE OF SATIETY IN RATS [J].
ANTIN, J ;
GIBBS, J ;
HOLT, J ;
YOUNG, RC ;
SMITH, GP .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1975, 89 (07) :784-790
[4]   Rikkunshito Improves the Symptoms in Patients with Functional Dyspepsia, Accompanied by an Increase in the Level of Plasma Ghrelin [J].
Arai, Makoto ;
Matsumura, Tomoaki ;
Tsuchiya, Naoko ;
Sadakane, Chiharu ;
Inami, Ryouhei ;
Suzuki, Takuto ;
Yoshikawa, Masaharu ;
Imazeki, Fumio ;
Yokosuka, Osamu .
HEPATO-GASTROENTEROLOGY, 2012, 59 (113) :62-66
[5]   Carboxypeptidase E Modulates Intestinal Immune Homeostasis and Protects against Experimental Colitis in Mice [J].
Baer, Florian ;
Foeh, Bandik ;
Pagel, Rene ;
Schroeder, Torsten ;
Schlichting, Heidi ;
Hirose, Misa ;
Lemcke, Susanne ;
Klinger, Antje ;
Koenig, Peter ;
Karsten, ChristianM. ;
Buening, Juergen ;
Lehnert, Hendrik ;
Fellermann, Klaus ;
Ibrahim, Saleh M. ;
Sina, Christian .
PLOS ONE, 2014, 9 (07)
[6]   Heart rate variability: Origins, methods, and interpretive caveats [J].
Berntson, GG ;
Bigger, JT ;
Eckberg, DL ;
Grossman, P ;
Kaufmann, PG ;
Malik, M ;
Nagaraja, HN ;
Porges, SW ;
Saul, JP ;
Stone, PH ;
VanderMolen, MW .
PSYCHOPHYSIOLOGY, 1997, 34 (06) :623-648
[7]   The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance [J].
Billman, George E. .
FRONTIERS IN PHYSIOLOGY, 2013, 4
[8]   Plasma Ghrelin Levels Are Associated with Anorexia but Not Cachexia in Patients with NSCLC [J].
Blauwhoff-Buskermolen, Susanne ;
Langius, Jacqueline A. E. ;
Heijboer, Annemieke C. ;
Becker, Annemarie ;
de van der Schueren, Marian A. E. ;
Verheul, Henk M. W. .
FRONTIERS IN PHYSIOLOGY, 2017, 8
[9]   Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment [J].
Bloechl-Daum, Brigitte ;
Deuson, Robert R. ;
Mavros, Panagiotis ;
Hansen, Mogens ;
Herrstedt, Jorn .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (27) :4472-4478
[10]   Gut Hormones, Appetite Suppression and Cachexia in Patients with Pulmonary TB [J].
Chang, Suzanne W. ;
Pan, William S. ;
Lozano Beltran, Daniel ;
Oleyda Baldelomar, Lizet ;
Antonio Solano, Marco ;
Tuero, Iskra ;
Friedland, Jon S. ;
Torrico, Faustino ;
Gilman, Robert H. .
PLOS ONE, 2013, 8 (01)
123456