Cystic kidney disease: the role of Wnt signaling

被引：65

作者：

Lancaster, Madeline A. ^{[1
]}

Gleeson, Joseph G. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, Program Biomed Sci, Howard Hughes Med Inst, San Diego, CA 92103 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2010年 / 16卷 / 08期

关键词：

PLANAR CELL POLARITY; BETA-CATENIN; PRIMARY CILIA; AUTOSOMAL-DOMINANT; GENETIC-BASIS; PROTEIN; ADULT; POLYCYSTIN-1; MECHANISMS; DIVISION;

D O I：

10.1016/j.molmed.2010.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling encompasses a variety of signaling cascades that can be activated by secreted Wnt ligands. Two such pathways, the canonical or beta-catenin pathway and the planar cell polarity (PCP) pathway, have recently received attention for their roles in multiple cellular processes within the kidney. Both of these pathways are important for kidney development as well as homeostasis and injury repair. The disruption of either pathway can lead to cystic kidney disease, a class of genetic diseases that includes the most common hereditary life-threatening syndrome polycystic kidney disease (PKD). Recent evidence implicates canonical and noncanonical Wnt pathways in cyst formation and points to a remarkable role for developmental processes in the adult kidney.

引用

页码：349 / 360

页数：12

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