Rhodium(III)-Catalyzed Cascade C-H Activation/Annulation of N-carbamoylindoles with Silyl Enol Ethers for the Construction of Dihydropyrimidoindolone Skeletons

被引：3

作者：

Chen, Lu ^{[1
]}

Wang, Zhichao ^{[1
]}

Pang, Binghan ^{[1
]}

Wang, Yangyang ^{[1
]}

Xu, Xiaobo ^{[1
]}

Wu, Gaorong ^{[1
]}

Ji, Yafei ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H activation; cascade annulation reaction; silyl enol ethers; N-carbamoylindoles; rhodium; NITROGEN-CONTAINING HETEROCYCLES; ONE-POT; ALPHA-ARYLATION; INDOLES; ANNULATION; ACTIVATION/CYCLIZATION; CYCLOMETALATION; ALKENYLATION; DERIVATIVES; CYCLIZATION;

D O I：

10.1002/ajoc.202100415

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route to 3,4-dihydropyrimido[1,6-a]indol-1(2H)-one derivatives enabled by Rh(III)-catalyzed cascade C-H activation/annulation of N-carbamoylindoles with silyl enol ethers has been reported. The reaction features mild conditions, wide substrate scope, diverse functional group tolerance and moderate to good yields. Furthermore, a plausible reaction mechanism is confirmed by an available rhodacycle intermediate.

引用

页码：2603 / 2610

页数：8

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