Detection of Gold Nanoparticles in Rat Organs by Transmission Electron Microscopy

被引：1
作者：
Platonova, T. A. [1 ]
Pridvorova, S. M. [1 ]
Zherdev, A. V. [1 ]
Gmoshinskii, I. V. [2 ]
Vasilevskaya, L. S. [2 ]
Dzantiev, B. B. [1 ]
机构：
[1] Russian Acad Sci, AN Bach Inst Biochem, Moscow, Russia
[2] Inst Nutr Res, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
gold nanoparticles; rat organ tissues; electron microscopy; LIVER; CELLS;
D O I：
10.1007/s10517-016-3318-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of water-dispersed gold nanoparticles (8.0 +/- 0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestinal mucosa and Peyer plaques, but also penetrated into other organs, e.g. liver and spleen. Ultrastructural changes in the cells (hyperplasia of endoplasmic reticulum) were detected in the studied organs.
引用
收藏
页码：817 / 822
页数：6
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