A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-β plaques

被引：64

作者：

Lim, SinChun ^{[2
,3
]}

Paterson, Brett M. ^{[2
,3
]}

Fodero-Tavoletti, Michelle T. ^{[1
,3
,4
]}

O'Keefe, Graeme J. ^{[5
]}

Cappai, Roberto ^{[3
,4
]}

Barnham, Kevin J. ^{[1
,3
,4
]}

Villemagne, Victor L. ^{[1
,5
]}

Donnelly, Paul S. ^{[2
,3
]}

机构：

[1] Mental Hlth Res Inst, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Inst Bio21, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[5] Austin Hosp, Ctr PET, Melbourne, Vic 3084, Australia

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 30期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

HYPOXIA SELECTIVITY; AGENTS; PET; MECHANISMS;

D O I：

10.1039/c0cc01175d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bis(thiosemicarbazonato)copper(II) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

引用

页码：5437 / 5439

页数：3

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