Avascular necrosis as a part of 'long COVID-19'

被引:68
作者
Agarwala, Sanjay R. [1 ]
Vijayvargiya, Mayank [2 ]
Pandey, Prashant [2 ]
机构
[1] PD Hinduja Natl Hosp, Orthopaed, Mumbai, Maharashtra, India
[2] PD Hinduja Natl Hosp & Med Res Ctr, Orthopaed, Mumbai, Maharashtra, India
关键词
COVID-19; musculoskeletal and joint disorders; unwanted effects; adverse reactions; groin pain; drugs; musculoskeletal and joint diseases; FEMORAL-HEAD; OSTEONECROSIS; PATHOGENESIS; THERAPY;
D O I
10.1136/bcr-2021-242101
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
'Long COVID-19' can affect different body systems. At present, avascular necrosis (AVN) as a sequalae of 'long COVID-19' has yet not been documented. By large-scale use of life-saving corticosteroids in COVID-19 cases, we anticipate that there will be a resurgence of AVN cases. We report a series of three cases in which patients developed AVN of the femoral head after being treated for COVID-19 infection. The mean dose of prednisolone used in these cases was 758 mg (400-1250 mg), which is less than the mean cumulative dose of around 2000 mg steroid, documented in the literature as causative for AVN. Patients were symptomatic and developed early AVN presentation at a mean of 58 days after COVID-19 diagnosis as compared with the literature which shows that it generally takes 6 months to 1 year to develop AVN post steroid exposure.
引用
收藏
页数:3
相关论文
共 13 条
[11]  
McKee MD, 2001, CAN MED ASSOC J, V164, P205
[12]   The pathogenesis of osteonecrosis and the relationships to corticosteroids [J].
Mirzai, R ;
Chang, C ;
Greenspan, A ;
Gershwin, ME .
JOURNAL OF ASTHMA, 1999, 36 (01) :77-95
[13]   Steroid induced osteonecrosis: An analysis of steroid dosing risk [J].
Powell, Christian ;
Chang, Christopher ;
Naguwa, Stanley M. ;
Cheema, Gurtej ;
Gershwin, M. Eric .
AUTOIMMUNITY REVIEWS, 2010, 9 (11) :721-743