Blood-brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

被引：65

作者：

Alajangi, Hema Kumari ^{[1
,2
]}

Kaur, Mandeep ^{[1
]}

Sharma, Akanksha ^{[1
,2
]}

Rana, Sumedh ^{[1
]}

Thakur, Shipali ^{[1
]}

Chatterjee, Mary ^{[3
]}

Singla, Neha ^{[1
]}

Jaiswal, Pradeep Kumar ^{[4
]}

Singh, Gurpal ^{[2
]}

Barnwal, Ravi Pratap ^{[1
]}

机构：

[1] Panjab Univ, Dept Biophys, Chandigarh 160014, India

[2] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[3] Panjab Univ, Dept Biotechnol, UIET, Chandigarh 160014, India

[4] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

来源：

MOLECULAR BRAIN | 2022年 / 15卷 / 01期

关键词：

Blood-brain barrier; BBB dysfunction; Drug delivery; Nanoparticles; Central nervous system; Neurological diseases; PEGYLATED LIPOSOMAL DOXORUBICIN; SOLID LIPID NANOPARTICLES; CENTRAL-NERVOUS-SYSTEM; PEG-PLA NANOPARTICLES; DRUG-DELIVERY; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; IN-VITRO; AUTOIMMUNE DISORDERS; SIGNALING PATHWAYS;

D O I：

10.1186/s13041-022-00937-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The integrity of the blood-brain barrier (BBB) is essential for normal central nervous system (CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the neural environment, we aim to provide an overview of significant aspects of BBB. Worldwide, the treatment of neurological diseases caused by BBB disruption has been a major challenge. BBB also restricts entry of neuro-therapeutic drugs and hinders treatment modalities. Hence, currently nanotechnology-based approaches are being explored on large scale as alternatives to conventional methodologies. It is necessary to investigate the in-depth characteristic features of BBB to facilitate the discovery of novel drugs that can successfully cross the barrier and target the disease effectively. It is imperative to discover novel strategies to treat life-threatening CNS diseases in humans. Therefore, insights regarding building blocks of BBB, activation of immune response on breach of this barrier, and various autoimmune neurological disorders caused due to BBB dysfunction are discussed. Further, special emphasis is given on delineating BBB disruption leading to CNS disorders. Moreover, various mechanisms of transport pathways across BBB, several novel strategies, and alternative routes by which drugs can be properly delivered into CNS are also discussed.

引用

页数：28

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