Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques

被引：13

作者：

Akhmedov, Shamil ^{[1
]}

Afanasyev, Sergey ^{[1
]}

Trusova, Marina ^{[2
]}

Postnikov, Pavel ^{[2
]}

Rogovskaya, Yulia ^{[1
]}

Grakova, Elena ^{[1
]}

Kopeva, Kristina ^{[1
]}

Paz, Rosa Karen Carreon ^{[3
]}

Balakin, Sascha ^{[3
]}

Wiesmann, Hans-Peter ^{[4
]}

Opitz, Joerg ^{[3
]}

Kruppke, Benjamin ^{[4
]}

Beshchasna, Natalia ^{[3
]}

Popov, Sergey ^{[1
]}

机构：

[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Cardiol Res Inst, Tomsk 634012, Russia

[2] Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk 634050, Russia

[3] Fraunhofer Inst Ceram Technol & Syst IKTS, D-01109 Dresden, Germany

[4] Tech Univ Dresden, Max Bergmann Ctr Biomat, Inst Mat Sci, D-01069 Dresden, Germany

来源：

BIOMEDICINES | 2021年 / 9卷 / 07期

关键词：

atherosclerosis; high density lipoprotein; chemically modified carbon-coated iron nanoparticle; reverse cholesterol transport; macrophage; coronary stent; DENSITY-LIPOPROTEIN FUNCTION; TOSYLATES;

D O I：

10.3390/biomedicines9070802

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques.

引用

页数：15

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