Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

被引：48

作者：

Hemmerling, Franziska ^{[1
,2
,3
]}

Hahn, Frank ^{[1
,2
,3
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, Schneiderberg 38, D-30167 Hannover, Germany

[2] Leibniz Univ Hannover, Zentrum Biomol Wirkstoffe, Schneiderberg 38, D-30167 Hannover, Germany

[3] Univ Bayreuth, Fak Biol Chem & Geowissensch, Univ Str 30, D-95440 Bayreuth, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷

关键词：

biosynthesis; chemoenzymatic synthesis; enzymology; heterocycles; polyketides; BERBERINE BRIDGE ENZYME; PSEUDOMONIC-ACID-A; POLYCYCLIC TETRAMATE MACROLACTAMS; VERSICONAL HEMIACETAL ACETATE; STREPTOMYCES-ALBUS JA3453; VERSICOLORIN B SYNTHASE; ACYL CARRIER PROTEIN; 1ST TOTAL-SYNTHESIS; AFLATOXIN BIOSYNTHESIS; GENE-CLUSTER;

D O I：

10.3762/bjoc.12.148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.

引用

页码：1512 / 1550

页数：39

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