Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

被引：50

作者：

Zimmerman, Ofer ^{[1
]}

Rosler, Berenice ^{[2
,3
]}

Zerbe, Christa S. ^{[1
]}

Rosen, Lindsey B. ^{[1
]}

Hsu, Amy P. ^{[1
]}

Uzel, Gulbu ^{[1
]}

Freeman, Alexandra F. ^{[1
]}

Sampaio, Elizabeth P. ^{[1
]}

Rosenzwieg, Sergio D. ^{[4
]}

Kuehn, Hye Sun ^{[4
]}

Kim, Tiffany ^{[5
]}

Brooks, Kristina M. ^{[5
]}

Kumar, Parag ^{[5
]}

Wang, Xiaowen ^{[2
,3
,6
]}

Netea, Mihai G. ^{[2
,3
]}

van de Veerdonk, Frank L. ^{[2
,3
]}

Holland, Steven M. ^{[1
]}

机构：

[1] Natl Inst Allergy & Immunol, Immunopathogenesis Sect, Lab Clin Infect Dis, NIH, Bethesda, MD USA

[2] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis RCI, Nijmegen, Netherlands

[4] NIH, Immunol Serv, Dept Lab Med, Natl Inst Clin Ctr, Bldg 10, Bethesda, MD 20892 USA

[5] NIH, Dept Pharm, Clin Ctr, Bethesda, MD 20892 USA

[6] Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China

来源：

OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 04期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

STAT1; gain of function; ruxolitinib; coccidiomycosis; dermatophytosis; CHRONIC MUCOCUTANEOUS CANDIDIASIS; SIGNAL TRANSDUCER; INCB018424; PHOSPHATE; HEALTHY-VOLUNTEERS; FUNCTION MUTATIONS; ACTIVATOR; PHARMACODYNAMICS; PHARMACOKINETICS; UNDERLIE;

D O I：

10.1093/ofid/ofx202

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

引用

页数：5

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