Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

被引：80

作者：

Yang, Bo ^{[1
]}

Zhou, Shan ^{[1
]}

Zeng, Jie ^{[1
]}

Zhang, Liping ^{[1
]}

Zhang, Runhao ^{[1
]}

Liang, Kang ^{[2
,3
]}

Xie, Lei ^{[1
]}

Shao, Bing ^{[4
]}

Song, Shaoli ^{[5
]}

Huang, Gang ^{[6
,7
]}

Zhao, Dongyuan ^{[1
]}

Chen, Pu ^{[8
]}

Kong, Biao ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, iChEM, Shanghai 200032, Peoples R China

[2] Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia

[3] Univ New South Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

[4] Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China

[5] Fudan Univ, Shanghai Canc Ctr, Dept Nucl Med, Shanghai 200032, Peoples R China

[6] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Clin Nucl Med, Shanghai 200127, Peoples R China

[8] Univ Waterloo, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada

来源：

NANO RESEARCH | 2020年 / 13卷 / 04期

基金：

上海市自然科学基金; 英国医学研究理事会; 中国国家自然科学基金;

关键词：

pH-responsive; photothermal therapy; metal-polyphenol complex; synergistic therapy; DRUG-DELIVERY; TUMOR; NANOSPHERES; REDOX; NANOCRYSTALS; COMPLEXES; CAPSULES; MICELLES; RELEASE; AGENT;

D O I：

10.1007/s12274-020-2736-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.

引用

页码：1013 / 1019

页数：7

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