Diagnostic Accuracy of Cardiac MRI versus FDG PET for Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis

被引：54

作者：

Aitken, Matthew ^{[1
]}

Chan, Michael Vinchill ^{[1
,8
]}

Fresno, Camila Urzua ^{[1
]}

Farrell, Ashley ^{[4
]}

Islam, Nayaar ^{[6
]}

McInnes, Matthew D. F. ^{[6
]}

Iwanochko, Mark ^{[2
]}

Balter, Meyer ^{[7
]}

Moayedi, Yasbanoo ^{[2
]}

Thavendiranathan, Paaladinesh ^{[1
,2
,5
]}

Metser, Ur ^{[1
,3
]}

Veit-Haibach, Patrick ^{[1
,3
]}

Hanneman, Kate ^{[1
,5
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Dept Med Imaging,Peter Munk Cardiac Ctr, 585 Univ Ave,1 PMB 298, Toronto, ON M5G 2N2, Canada

[2] Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Cardiol,Peter Munk Cardiac Ctr, 585 Univ Ave,1 PMB 298, Toronto, ON M5G 2N2, Canada

[3] Univ Toronto, Univ Hlth Network, Toronto Gen Hosp, Div Mol Imaging, 585 Univ Ave,1 PMB 298, Toronto, ON M5G 2N2, Canada

[4] Univ Toronto, Univ Hlth Network, Dept Lib & Informat Serv, Toronto, ON, Canada

[5] Univ Toronto, Univ Hlth Network, Toronto Gen Hosp Res Inst, Toronto, ON, Canada

[6] Univ Ottawa, Dept Radiol & Epidemiol, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[7] Univ Toronto, Div Resp Med, Sinai Hlth Syst, Toronto, ON, Canada

[8] Univ Sydney, Concord Hosp Clin Sch, Dept Radiol, Sydney, NSW, Australia

来源：

RADIOLOGY | 2022年 / 304卷 / 03期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE; F-18-FDG PET; INVOLVEMENT;

D O I：

10.1148/radiol.213170

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: There is limited consensus regarding the relative diagnostic performance of cardiac MRI and fluorodeoxyglucose (FDG) PET for cardiac sarcoidosis. Purpose: To perform a systematic review and meta-analysis to compare the diagnostic accuracy of cardiac MRI and FDG PET for cardiac sarcoidosis. Materials and Methods: Medline, Ovid Epub, Cochrane Central Register of Controlled Trials, Embase, Emcare, and Scopus were searched from inception until January 2022. Inclusion criteria included studies that evaluated the diagnostic accuracy of cardiac MRI or FDG PET for cardiac sarcoidosis in adults. Data were independently extracted by two investigators. Summary accuracy metrics were obtained by using bivariate random-effects meta-analysis. Meta-regression was used to assess the effect of different covariates. Risk of bias was assessed using the Quality Assessment Tool for Diagnostic Accuracy Studies-2 tool. The study protocol was registered a priori in the International Prospective Register of Systematic Reviews (Prospero protocol CRD42021214776). Results: Thirty-three studies were included (1997 patients, 687 with cardiac sarcoidosis); 17 studies evaluated cardiac MRI (1031 patients) and 26 evaluated FDG PET (1363 patients). Six studies directly compared cardiac MRI and PET in the same patients (303 patients). Cardiac MRI had higher sensitivity than FDG PET (95% vs 84%; P..002), with no difference in specificity (85% vs 82%; P..85). In a sensitivity analysis restricted to studies with direct comparison, point estimates were similar to those from the overall analysis: cardiac MRI and FDG PET had sensitivities of 92% and 81% and specificities of 72% and 82%, respectively. Covariate analysis demonstrated that sensitivity for FDG PET was highest with quantitative versus qualitative evaluation (93% vs 76%; P..01), whereas sensitivity for MRI was highest with inclusion of T2 imaging (99% vs 88%; P..001). Thirty studies were at risk of bias. Conclusion: Cardiac MRI had higher sensitivity than fluorodeoxyglucose PET for diagnosis of cardiac sarcoidosis but similar specificity. Limitations, including risk of bias and few studies with direct comparison, necessitate additional study. (C) RSNA, 2022

引用

页码：566 / 579

页数：14

共 63 条

[1] Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis [J].