Convenient Access to Polyfunctional Pyrazoles via a Highly Efficient and Regioselective Multicomponent Reaction

被引：35

作者：

Shu, Wen-Ming ^{[1
]}

Zheng, Kai-Lu ^{[1
]}

Ma, Jun-Rui ^{[1
]}

Sun, Hui-Ying ^{[1
]}

Wang, Mei ^{[1
]}

Wu, An-Xin ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; DEHYDROGENATIVE CYCLIZATION; 1,3-DIPOLAR CYCLOADDITIONS; HYDRAZONES; INHIBITORS; KETONES; NITROOLEFINS; ALDEHYDES;

D O I：

10.1021/acs.orglett.5b00605

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A multicomponent reaction has been developed for the synthesis of polyfunctional pyrazole derivatives from readily available arylglyoxal monohydrates, tosylhydrazine, and aldehydes or ketones. This synthetic method has significant advantages in broad substrate scope, excellent regioselectivity, and simple operation.

引用

收藏

页码：1914 / 1917

页数：4

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