The impact of medical therapies and factors related to treatment procedures in women with rheumatoid arthritis and inflammatory bowel disease receiving assisted reproduction: a nationwide cohort study

被引：7

作者：

Norgard, Bente Mertz ^{[1
,2
]}

Wod, Mette ^{[1
,2
]}

Larsen, Michael Due ^{[1
,3
]}

Friedman, Sonia ^{[2
,4
]}

Jolving, Line Riis ^{[1
,2
]}

Fedder, Jens ^{[5
,6
]}

机构：

[1] Odense Univ Hosp, Ctr Clin Epidemiol, Sdr Blvd 29,Entrance 216, DK-5000 Odense C, Denmark

[2] Univ Southern Denmark, Res Unit Clin Epidemiol, Dept Clin Res, Odense, Denmark

[3] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway

[4] Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, Dept Med, Boston, MA 02115 USA

[5] Odense Univ Hosp, Ctr Androl & Fertil Clin, Odense, Denmark

[6] Univ Southern Denmark, Dept Clin Res, Res Unit Gynecol & Obstet, Odense, Denmark

来源：

FERTILITY AND STERILITY | 2021年 / 116卷 / 06期

关键词：

ART; inflammatory bowel disease; live birth; rheumatoid arthritis; INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; CIVIL REGISTRATION SYSTEM; MALE-FACTOR INFERTILITY; ULCERATIVE-COLITIS; EMBRYO-TRANSFER; CROHNS-DISEASE; LIVE BIRTH; DANISH; FERTILITY;

D O I：

10.1016/j.fertnstert.2021.07.1198

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To examine whether medications used to treat rheumatoid arthritis (RA)/chronic inflammatory bowel disease (IBD), or factors related to the assisted reproductive technology (ART) procedures, impact the success of ART. In women with RA/IBD, initial studies have shown a reduced chance of a live-born child after ART. Design: Cohort study. Setting: Nationwide Danish health registries. Patients: All Danish women with a fresh embryo transfer from January 1, 2006, through 2018. The cohorts comprised 1,824 embryo transfers in women with RA/IBD and 97,191 embryo transfers in women without RA/IBD. Interventions: Observational, noninterventional study. Main Outcome Measure: Live birth per fresh embryo transfer. Results: The chance of a live birth in women with RA/IBD receiving ART, compared with other women receiving ART, had an adjusted odds ratio (OR) of 0.79 (95% confidence interval [CI], 0.68-0.91). Prescribed corticosteroids before embryo transfer were positively associated with a live-born child (adjusted OR, 1.21; 95% CI, 1.12-1.31), while the use of antiinflammatory/immunosuppressive agents did not have significant importance. Intracytoplasmic sperm injection was associated with a reduced chance (adjusted OR, 0.94; 95% CI, 0.90-0.97). Type of hormone treatment protocol did not have significant importance, and transfer at the blastocyst stage was positively associated with a live-born child (adjusted OR, 1.54; 95% CI, 1.46-1.62). Conclusions: In women with RA and/or IBD, prescribed corticosteroid before embryo transfer and embryo transfer at the blastocyst stage were associated with successful ART. Intracytoplasmic sperm injection was associated with a slightly reduced chance. Antiinflammatory/immunosuppressive agents and type of hormone protocols did not have significant importance. (C) 2021 by American Society for Reproductive Medicine.)

引用

页码：1492 / 1500

页数：9

共 45 条

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