Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

被引：94

作者：

Le Sage, Valerie ^{[1
]}

Cinti, Alessandro ^{[1
,2
]}

Amorim, Raquel ^{[1
,2
]}

Mouland, Andrew J. ^{[1
,2
]}

机构：

[1] Jewish Gen Hosp, Lady Davis Inst, HIV RNA Trafficking Lab 1, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3A 0G4, Canada

来源：

VIRUSES-BASEL | 2016年 / 8卷 / 06期

基金：

加拿大健康研究院;

关键词：

PI3K; Akt; mTOR; virus; 4EBP1; autophagy; HEPATITIS-C VIRUS; INFLUENZA-A VIRUS; HUMAN CYTOMEGALOVIRUS-INFECTION; MIDDLE T-ANTIGEN; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION; ENDOPLASMIC-RETICULUM STRESS; MESSENGER-RNA TRANSLATION; PROTEIN-COUPLED RECEPTOR; HUMAN EPITHELIAL-CELLS; AKT/PROTEIN KINASE-B;

D O I：

10.3390/v8060152

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs.

引用

页数：19

共 152 条

[1] Proteomic Analysis of Chikungunya Virus Infected Microgial Cells [J].

Abere, Bizunesh ;

Wikan, Nitwara ;

Ubol, Sukathida ;

Auewarakul, Prasert ;

Paemanee, Atchara ;

Kittisenachai, Suthathip ;

Roytrakul, Sittiruk ;

Smith, Duncan R. .

PLOS ONE, 2012, 7 (04)

[2] PATHOGENESIS OF PORCINE CIRCOVIRUS - EXPERIMENTAL INFECTIONS OF COLOSTRUM DEPRIVED PIGLETS AND EXAMINATION OF PIG FETAL MATERIAL [J].

ALLAN, GM ;

MCNEILLY, F ;

CASSIDY, JP ;

REILLY, GAC ;

ADAIR, B ;

ELLIS, WA ;

MCNULTY, MS .

VETERINARY MICROBIOLOGY, 1995, 44 (01) :49-64

[3] mTOR regulates memory CD8 T-cell differentiation [J].

Araki, Koichi ;

Turner, Alexandra P. ;

Shaffer, Virginia Oliva ;

Gangappa, Shivaprakash ;

Keller, Susanne A. ;

Bachmann, Martin F. ;

Larsen, Christian P. ;

Ahmed, Rafi .

NATURE, 2009, 460 (7251) :108-U124

[4] Disruption of Akt kinase activation is important for immunosuppression induced by measles virus [J].

Avota, E ;

Avots, A ;

Niewiesk, S ;

Kane, LP ;

Bommhardt, U ;

ter Meulen, V ;

Schneider-Schaulies, S .

NATURE MEDICINE, 2001, 7 (06) :725-731

[5] Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38 [J].

Bai, Yadan ;

Xuan, Baoqin ;

Liu, Haiyan ;

Zhong, Jin ;

Yu, Dong ;

Qian, Zhikang .

JOURNAL OF VIROLOGY, 2015, 89 (15) :7625-7635

[6] Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1 [J].

Bar-Peled, Liron ;

Schweitzer, Lawrence D. ;

Zoncu, Roberto ;

Sabatini, David M. .

CELL, 2012, 150 (06) :1196-1208

[7] West Nile virus growth is independent of autophagy activation [J].

Beatman, Erica ;

Oyer, Ryan ;

Shives, Katherine D. ;

Hedman, Karla ;

Brault, Aaron C. ;

Tyler, Kenneth L. ;

Beckham, J. David .

VIROLOGY, 2012, 433 (01) :262-272

[8] Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of ΔUS3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1 [J].

Benetti, L ;

Roizman, B .

JOURNAL OF VIROLOGY, 2006, 80 (07) :3341-3348

[9] Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells [J].

Bianchini, Andrea ;

Loiarro, Maria ;

Bielli, Pamela ;

Busa, Roberta ;

Paronetto, Maria Paola ;

Loreni, Fabrizio ;

Geremia, Raffaele ;

Sette, Claudio .

CARCINOGENESIS, 2008, 29 (12) :2279-2288

[10] Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses [J].

Blanchet, Fabien P. ;

Moris, Arnaud ;

Nikolic, Damjan S. ;

Lehmann, Martin ;

Cardinaud, Sylvain ;

Stalder, Romaine ;

Garcia, Eduardo ;

Dinkins, Christina ;

Leuba, Florence ;

Wu, Li ;

Schwartz, Olivier ;

Deretic, Vojo ;

Piguet, Vincent .

IMMUNITY, 2010, 32 (05) :654-669

← 1 2 3 4 5 6 7 8 9 10 →