Menopausal symptoms and fertility concerns in premenopausal breast cancer survivors: a comparison to age- and gravidity-matched controls

被引:58
作者
Ruddy, Kathryn J. [1 ]
Gelber, Shari [1 ]
Ginsburg, Elizabeth S. [2 ]
Schapira, Lidia [3 ]
Abusief, Mary E. [2 ]
Meyer, Meghan E. [1 ]
Partridge, Ann H. [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Boston, MA 02114 USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2011年 / 18卷 / 01期
关键词
Hot flashes; Menopause; premature; Infertility; Anxiety; QUALITY-OF-LIFE; SURGICAL ADJUVANT BREAST; YOUNG-WOMEN; PREVENTION; TAMOXIFEN; TRIAL;
D O I
10.1097/gme.0b013e3181ef39f8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Many young breast cancer survivors experience menopausal symptoms and feel concerned about infertility due to oncologic treatment. However, there has been little research to date comparing young survivors' concerns and symptoms with those of young women of the same age and gravidity in the general population. Methods: We surveyed breast cancer survivors with regular menses after adjuvant chemotherapy and compared them with age-matched, gravidity-matched controls as part of a study to evaluate the effects of chemotherapy on ovarian reserve. All survivors were 1 year or more from diagnosis of early-stage breast cancer, without evidence of recurrence. The survey assessed menopausal symptoms and infertility concerns. Results: The study was stopped after a planned interim analysis of the first 20 matched pairs revealed significantly diminished measures of ovarian reserve in survivors compared with controls. Mean age was 37 years for both groups (range, 31-43 y). Eighty percent of survivors and 25% of controls expressed some concern regarding fertility at the time of the survey (P = 0.001). Survivors were more likely to report bothersome menopausal symptoms than were controls (P = 0.05). An exploratory analysis revealed that menopausal symptoms were greatest in the survivors taking tamoxifen. Conclusions: Young women who remained premenopausal after breast cancer chemotherapy expressed greater concern about fertility and reported more menopausal symptoms than did age- and gravidity-matched controls. This may have been due to cancer diagnosis or treatment, or it may reflect other differences between the survivors and controls in this study. Additional research is warranted to determine how to most effectively address fertility concerns and reduce symptom burden in this population.
引用
收藏
页码:105 / 108
页数:4
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