Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

被引：23

作者：

Sun, Wan ^{[1
]}

Cui, Jing-Xue ^{[1
]}

Ma, Le-Le ^{[1
]}

Lu, Zhong-Lin ^{[1
]}

Gong, Bing ^{[1
]}

He, Lan ^{[2
]}

Wang, Ruibing ^{[3
,4
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Xinjiekouwai St 19, Beijing 100875, Peoples R China

[2] Natl Inst Food & Drug Control, Beijing 100050, Peoples R China

[3] Univ Macau, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

[4] Univ Macau, Inst Chinese Med Sci, Taipa, Macau, Peoples R China

来源：

ANALYST | 2018年 / 143卷 / 23期

关键词：

TRIPHENYLAMINE; DERIVATIVES; DESIGN; SENSOR;

D O I：

10.1039/c8an01643g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

引用

页码：5799 / 5804

页数：6

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