Atrial fibrillation in Brugada syndrome: Current perspectives

被引：26

作者：

Vlachos, Konstantinos ^{[1
,2
]}

Mascia, Giuseppe ^{[3
]}

Martin, Claire A. ^{[1
,2
,4
]}

Bazoukis, George ^{[5
]}

Frontera, Antonio ^{[1
,2
]}

Cheniti, Ghassen ^{[1
,2
]}

Letsas, Konstantinos P. ^{[5
]}

Efremidis, Micheal ^{[5
]}

Georgopoulos, Stamatis ^{[5
]}

Gkalapis, Charis ^{[6
,7
]}

Duchateau, Josselin ^{[1
,2
]}

Parmbrun, Thomas ^{[1
,2
]}

Derval, Nicholas ^{[1
,2
]}

Hocini, Meleze ^{[1
,2
]}

Haissaguerre, Michel ^{[1
,2
]}

Jais, Pierre ^{[1
,2
]}

Sacher, Frederic ^{[1
,2
]}

机构：

[1] CHU Bordeaux, Hop Cardiol Haut Leveque, Pessac, France

[2] IHU LIRYC, Pessac, France

[3] Azienda USL Toscana, Cardiol & Electrophysiol Unit, Florence, Italy

[4] Royal Papworth Hosp, Dept Electrophysiol Cardiol, Cambridge, England

[5] Gen Hosp Athens Evangelismos, Dept Cardiol 2, Lab Electrophysiol, Athens, Greece

[6] Klinikum Vest, Dept Electrophysiol Cardiol, Recklinghausen, Germany

[7] Ruhr Univ Bochum, Akad Lehrkrankenhaus, Dept Cardiol, Bochum, Germany

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2020年 / 31卷 / 04期

关键词：

arrhythmia mechanism; atrial fibrillation; Brugada syndrome; genetics; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; SUDDEN CARDIAC DEATH; PULMONARY VEIN ISOLATION; ST-SEGMENT ELEVATION; HIGH-RISK; SUPRAVENTRICULAR TACHYARRHYTHMIAS; CATHETER ABLATION; PREVALENCE; MANAGEMENT; SYNCOPE;

D O I：

10.1111/jce.14361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of atrial fibrillation (AF) in Brugada syndrome (BrS) has been reported at between 9% and 53% by different series, but the true prevalence is unknown. However, AF may be the presenting feature in some patients. The underlying mechanisms for AF may be a combination of multiple factors, genetic or acquired, that may impact upon autonomic function, atrial structure, and conduction velocities or other unknown factors. The presence of AF has been associated with a more malignant course, with a greater incidence of syncope and ventricular arrhythmias, thus acting as marker of more advanced disease. Regarding the management of patients with AF, antiarrhythmic drugs effective in preventing malignant arrhythmias in BrS such as quinidine or invasive treatment with pulmonary vein isolation (PVI) may be useful in AF treatment. In this review, we aim to present the current perspectives regarding the genetics, pathophysiology, management, and prognosis of AF in patients with BrS.

引用

页码：975 / 984

页数：10

共 85 条

[1] Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
Abraham, Robert L.
Yang, Tao
Blair, Marcia
Roden, Dan M.
Darbar, Dawood
[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2010, 48 (01) : 181 - 190
[2] Brugada syndrome: diagnosis, risk stratification, and management
Adler, Arnon
[J]. CURRENT OPINION IN CARDIOLOGY, 2016, 31 (01) : 37 - 45
[3] Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome
Amin, Ahmad S.
Boink, Gerard J. J.
Atrafi, Florence
Spanjaart, Anne M.
Asghari-Roodsari, Alaleh
Molenaar, Remco J.
Ruijter, Jan M.
Wilde, Arthur A. M.
Tan, Hanno L.
[J]. EUROPACE, 2011, 13 (07): : 968 - 975
[4] Brugada syndrome - Report of the second consensus conference - Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
Antzelevitch, C
Brugada, P
Borggrefe, M
Brugada, J
Brugada, R
Corrado, D
Gussak, I
LeMarec, H
Nademanee, K
Riera, ARP
Shimizu, W
Schulze-Bahr, E
Tan, H
Wilde, A
[J]. CIRCULATION, 2005, 111 (05) : 659 - 670
[5] The Brugada syndrome: Ionic basis and arrhythmia mechanisms
Antzelevitch, C
[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2001, 12 (02) : 268 - 272
[6] Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-Segment elevation, short QT intervals, and sudden cardiac death
Antzelevitch, Charles
Pollevick, Guido D.
Cordeiro, Jonathan M.
Casis, Oscar
Sanguinetti, Michael C.
Aizawa, Yoshiyasu
Guerchicoff, Alejandra
Pfeiffer, Ryan
Oliva, Antonio
Wollnik, Bernd
Gelber, Philip
Bonaros, Elias P., Jr.
Burashnikov, Elena
Wu, Yuesheng
Sargent, John D.
Schickel, Stefan
Oberheiden, Ralf
Bhatia, Atul
Hsu, Li-Fern
Haissaguerre, Michel
Schimpf, Rainer
Borggrefe, Martin
Wolpert, Christian
[J]. CIRCULATION, 2007, 115 (04) : 442 - 449
[7] Brugada syndrome
Antzelevitch, Charles
[J]. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2006, 29 (10): : 1130 - 1159
[8] Management of Brugada Syndrome Thirty-Three-Year Experience Using Electrophysiologically Guided Therapy With Class 1A Antiarrhythmic Drugs
Belhassen, Bernard
Rahkovich, Michael
Michowitz, Yoav
Glick, Aharon
Viskin, Sami
[J]. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2015, 8 (06) : 1393 - 1402
[9] Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Bezzina, Connie R.
Barc, Julien
Mizusawa, Yuka
Remme, Carol Ann
Gourraud, Jean-Baptiste
Simonet, Floriane
Verkerk, Arie O.
Schwartz, Peter J.
Crotti, Lia
Dagradi, Federica
Guicheney, Pascale
Fressart, Veronique
Leenhardt, Antoine
Antzelevitch, Charles
Bartkowiak, Susan
Schulze-Bahr, Eric
Zumhagen, Sven
Behr, Elijah R.
Bastiaenen, Rachel
Tfelt-Hansen, Jacob
Olesen, Morten Salling
Kaeaeb, Stefan
Beckmann, Britt M.
Weeke, Peter
Watanabe, Hiroshi
Endo, Naoto
Minamino, Tohru
Horie, Minoru
Ohno, Seiko
Hasegawa, Kanae
Makita, Naomasa
Nogami, Akihiko
Shimizu, Wataru
Aiba, Takeshi
Froguel, Philippe
Balkau, Beverley
Lantieri, Olivier
Torchio, Margherita
Wiese, Cornelia
Weber, David
Wolswinkel, Rianne
Coronel, Ruben
Boukens, Bas J.
Bezieau, Stephane
Charpentier, Eric
Chatel, Stephanie
Despres, Aurore
Gros, Francoise
Kyndt, Florence
Lecointe, Simon
[J]. NATURE GENETICS, 2013, 45 (09) : 1044 - +
[10] Clinical predictors of atrial fibrillation in Brugada syndrome
Bigi, Mohamad Ali Babai
Aslani, Arnir
Shahrzad, Shahab
[J]. EUROPACE, 2007, 9 (10): : 947 - 950

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