Acute myeloid leukemia secondary to acute B lymphoblastic leukemia treated with maintenance therapy in a child: A case report

被引：0
作者：
Wang, Xiaoning [1 ]
Ding, Ding [2 ]
Liu, Yalin [1 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Hematol, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Dept Pediat, Affiliated Hosp 1, Xian, Peoples R China
来源：
CANCER REPORTS | 2022年 / 5卷 / 11期
关键词：
acute lymphoblastic leukemia; acute myeloid leukemia; secondary malignancy; IDARUBICIN; AML;
D O I：
10.1002/cnr2.1717
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Acute lymphoblastic leukemia (ALL) has the highest incidence among childhood hematologic cancers. Exposure to certain cytotoxic therapies for ALL is correlated with a higher risk of secondary malignancies. Case We report a rare case of a 6-year-old girl being diagnosed with secondary acute myeloid leukemia (AML) during her maintenance phase of treatment for ALL with TEL-AML1 fusion gene, approximately 17 months after the primary diagnosis. Conclusion This case indicates that we should recognize the increased risk of secondary AML for pediatric ALL patients with TEL-AML1 fusion gene if multiple alkylating drugs and inhibitors for topoisomerase II are included in induction chemotherapy.
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页数：5
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