Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer

被引：6

作者：

Dong, Xiaoxi ^{[1
]}

Zheng, Tiantian ^{[1
]}

Zhang, Minhua ^{[2
]}

Dai, Chao ^{[1
]}

Wang, Lili ^{[3
]}

Wang, Lei ^{[3
]}

Zhang, Ruipeng ^{[2
]}

Long, Yuan ^{[4
]}

Wen, Danyi ^{[5
]}

Xie, Feng ^{[6
]}

Zhang, Yue ^{[6
]}

Huang, Yong ^{[6
]}

Dong, Jianguo ^{[6
]}

Liu, Huan ^{[7
]}

Du, Pan ^{[1
]}

King, Bonnie L. ^{[1
]}

Tan, Winston ^{[8
]}

Jia, Shidong ^{[1
]}

Lu, Chris X. ^{[9
]}

Kohli, Manish ^{[10
]}

Wang, Haitao ^{[3
]}

Yu, Jianjun ^{[1
]}

机构：

[1] Predicine Inc, Hayward, CA 94545 USA

[2] Laekna Therapeut Shanghai Co Ltd, Dept Translat Med, Shanghai, Peoples R China

[3] Tianjin Med Univ, Dept Oncol, Hosp 2, Tianjin, Peoples R China

[4] Shanghai Lide Biotech Co Ltd, Dept New Assay Dev, Shanghai, Peoples R China

[5] Shanghai Lide Biotech Co Ltd, Shanghai, Peoples R China

[6] Huidu Shanghai Med Sci Ltd, Shanghai, Peoples R China

[7] Shanghai Lide Biotech Co Ltd, Dept Biol, Shanghai, Peoples R China

[8] Mayo Clin, Div Med Oncol, Dept Med, Jacksonville, FL 32224 USA

[9] Laekna Therapeut Shanghai Co Ltd, Shanghai, Peoples R China

[10] Univ Utah, Dept Internal Med, Huntsman Canc Inst, Div Oncol, Salt Lake City, UT 84112 USA

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

liquid biopsy; circulating tumor DNA; copy number loss; prostate cancer; NGS; RESISTANCE;

D O I：

10.3389/fonc.2021.720727

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.

引用

页数：7

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