Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes

被引：47

作者：

Greenberg, Peter L. ^{[1
]}

Koller, Charles A. ^{[2
]}

Cabantchik, Z. Ioav ^{[3
]}

Warsi, Ghulam ^{[4
]}

Glynos, Tara ^{[4
]}

Paley, Carole ^{[4
]}

Schiffer, Charles ^{[5
]}

机构：

[1] Stanford Univ, Ctr Canc, Div Hematol, Stanford, CA 94305 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Hebrew Univ Jerusalem, Jerusalem, Israel

[4] Novartis Pharmaceut, E Hanover, NJ USA

[5] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 12期

关键词：

Iron chelation; Deferasirox; Exjade (R); MDS; Pharmacokinetics; MRI; LABILE PLASMA IRON; MAGNETIC-RESONANCE; MYOCARDIAL IRON; THALASSEMIA MAJOR; BETA-THALASSEMIA; HEMOCHROMATOSIS; CHELATION; MUTATIONS; DISEASE; ANEMIAS;

D O I：

10.1016/j.leukres.2010.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the first prospective study evaluating the effects of deferasirox on liver iron concentration (LIC), labile plasma iron (LPI) and pharmacokinetics (PK) along with serum ferritin values in patients with IPSS Low-and Intermediate-1 risk myelodysplastic syndromes (MDS) and evidence of iron overload. Twenty-four heavily transfused MDS patients were enrolled in a planned 52 weeks of therapy. PK studies showed dose-proportional total drug exposure. Data demonstrated that deferasirox was well tolerated and effectively reduced LIC, LPI and serum ferritin in the iron-overloaded patients with MDS who completed 24 and 52 weeks of therapy despite ongoing receipt of red blood cell transfusions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1560 / 1565

页数：6

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