Study of hypoxia-induced expression of HIF-1α in retina pigment epithelium

被引：5

作者：

Yapjun, Zeng ^{[1
]}

Guangyu, Li

Bin, Fan

Qing, Wang

Ying, Jie

Aizhen, Liu

机构：

[1] Univ Technol Beijing, Biomech & Med Informat, Beijing, Peoples R China

[2] Hosp Jilin Univ 2, Dept Ophthalmol, Changchun, Peoples R China

[3] Hong Kong Polytech Univ, Rehabil Engn Ctr, Hong Kong, Hong Kong, Peoples R China

[4] Beijing Tongren Eye Ctr, Dept Opt, Beijing, Peoples R China

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 143卷 / 03期

基金：

中国国家自然科学基金;

关键词：

choriodal neovascularization; HIF-1; alpha; hypoxia; retinal pigment epithelium;

D O I：

10.1007/s10517-007-0101-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It was shown that the expression of HIF-1 alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1 alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1 alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1 alpha in RPE. It can be an important step in choriodal neovascularization.

引用

页码：323 / 327

页数：5

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