Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights

被引：29

作者：

Fransen, Marieke F. ^{[1
,2
]}

van Hall, Thorbald ^{[3
]}

Ossendorp, Ferry ^{[1
]}

机构：

[1] Leiden Univ Med Ctr LUMC, Dept Immunol, NL-2300 RC Leiden, Netherlands

[2] Univ Amsterdam, Dept Pulm Dis, Med Ctr, NL-1081 HV Amsterdam, Netherlands

[3] Leiden Univ Med Ctr LUMC, Dept Med Oncol, NL-2300 RC Leiden, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

cancer; immunotherapy; tumor-draining lymph nodes; checkpoint blockers; neoadjuvant; CD8(+) T-CELLS; NEOADJUVANT IMMUNOTHERAPY; MELANOMA; ACTIVATION; SUBSETS; EGRESS; INHIBITION; IMMUNOLOGY; MIGRATION; RESPONSES;

D O I：

10.3390/ijms22179401

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor-draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treatment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of dedicated immune cells. In view of the success of immunotherapy, the removal of tumor-draining lymph nodes needs to be re-evaluated and viewed in a different light. Recently, an important role for tumor-draining lymph nodes has been proposed in the immunotherapy of cancer. This new insight can change the use of immune checkpoint therapy, particularly with respect to the use in neoadjuvant settings in which lymph nodes are still operational.

引用

页数：10

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