The intestinal flora influences adhesion formation around surgical anastomoses

被引：38

作者：

Bothin, C

Okada, M

Midtvedt, T

Perbeck, L

机构：

[1] Karolinska Inst, Dept Med Microbial Ecol, S-17177 Stockholm, Sweden

[2] Jichi Med Sch, Dept Surg, Minami Kawachi, Tochigi, Japan

[3] Huddinge Univ Hosp, Karolinska Inst, Dept Surg, Stockholm, Sweden

来源：

BRITISH JOURNAL OF SURGERY | 2001年 / 88卷 / 01期

关键词：

D O I：

10.1046/j.1365-2168.2001.01613.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Postsurgical adhesion formation is still a cause of postoperative morbidity because no satisfactory treatment or prophylaxis has yet been developed. The present study was designed to investigate the influence of the gastrointestinal flora on adhesion formation around surgical anastomoses. Methods: Anastomoses were constructed in germfree, conventional, ex-germfree and monocontaminated rats (Escherichia coli X7 and Lactobacillus acidophillus La5), and adhesion formation was recorded. Results: The germfree group had a significantly lower adhesion score than all other groups (P < 0.05) apart from the lactobacillus group, which had a significantly lower score than the conventional group (P < 0.05). Conclusion: The bacterial flora of the gastrointestinal tract enhances adhesion formation around surgical anastomoses.

引用

页码：143 / 145

页数：3

共 8 条

[1]

Bothin CG, 1999, J INVEST SURG, V12, P147

[2]

DIZEREGA GS, 1994, FERTIL STERIL, V61, P219

[3] AETIOLOGY OF POST-OPERATIVE ABDOMINAL ADHESIONS - AN EXPERIMENTAL STUDY [J].