Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective PlatinumIV Prodrug Against Triple Negative Breast Cancer

被引：8

作者：

Muhammad, Nafees ^{[1
]}

Cai-Ping, Tan ^{[1
]}

Nasreen, Sadia ^{[2
]}

Mao, Zong-Wan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China

[2] Univ Engn & Technol, Dept Environm Engn, Taxila 47080, Pakistan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2021年 / 16卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Platinum(IV); Doxorubicin; Triple negative breast cancer; Mitochondria; Necrosis; COMPLEXES; RESISTANCE;

D O I：

10.1002/asia.202100593

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mitochondria targeting dual-action platinum(IV) prodrug exhibits high anticancer activity in triple negative breast cancer cells. The complex intervenes in several cellular processes including DNA damage, perturbation of mitochondrial bioenergetics and induction of necrosis to kill cancer cells.

引用

页码：2276 / 2279

页数：4

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