Mass attenuation coefficients, effective atomic numbers and electron densities of some contrast agents for computed tomography

被引：118

作者：

Al-Buriahi, Mohammed Sultan ^{[1
]}

Tonguc, Baris T. ^{[1
]}

机构：

[1] Sakarya Univ, Dept Phys, Sakarya, Turkey

来源：

RADIATION PHYSICS AND CHEMISTRY | 2020年 / 166卷

关键词：

Mass attenuation coefficient; Effective atomic number; Electron density; CT contrast agent; Geant4; DOSIMETRIC MATERIALS; DOSE CALCULATIONS; PHYSICS MODELS; HUMAN TISSUES; LIQUID WATER; GEANT4; PHOTON; GLASSES; WINXCOM; XCOM;

D O I：

10.1016/j.radphyschem.2019.108507

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the clinical computed tomography (CT) examinations, a photon is attenuated as it passes a patient by tissues and contrast agents (CAs). The CM can increase the visibility of internal structures or fluids within the patient. In this work, we have investigated the photon interaction parameters of some CT contrast agents such as iotrolan, iodixanol, iohexol, ioxilan, ioversol, and iomeprol. The mass attenuation coefficients (mu/rho) of these contrast agents have been determined using Geant4 code in the energy range from 1 keV to 1 MeV for total photon interaction. The validity of the Geant4 code was verified by comparing the simulation results with those calculated by the XCOM program. A very good agreement was observed between mu/rho values obtained by both Geant4 and XCOM codes. The mu/rho values were then used to estimate the effective atomic numbers (Z(eff)) and electron densities (N-eff) for the selected CT contrast agents. It was found that the values of mu/rho, Z(eff) and N-eff depend on the photon energy and increase with increasing iodine concentration in the composition of CAs. Also, the Z(eff) values were observed in the range of 6-50 and the N-eff values were observed in the range of 2 - 21 (10(23) electron/g). The present study would be helpful to develop new CT contrast agents to serve in vivo imaging applications.

引用

页数：6

共 43 条

[1] GEANT4-a simulation toolkit [J].

Agostinelli, S ;

Allison, J ;

Amako, K ;

Apostolakis, J ;

Araujo, H ;

Arce, P ;

Asai, M ;

Axen, D ;

Banerjee, S ;

Barrand, G ;

Behner, F ;

Bellagamba, L ;

Boudreau, J ;

Broglia, L ;

Brunengo, A ;

Burkhardt, H ;

Chauvie, S ;

Chuma, J ;

Chytracek, R ;

Cooperman, G ;

Cosmo, G ;

Degtyarenko, P ;

Dell'Acqua, A ;

Depaola, G ;

Dietrich, D ;

Enami, R ;

Feliciello, A ;

Ferguson, C ;

Fesefeldt, H ;

Folger, G ;

Foppiano, F ;

Forti, A ;

Garelli, S ;

Giani, S ;

Giannitrapani, R ;

Gibin, D ;

Cadenas, JJG ;

González, I ;

Abril, GG ;

Greeniaus, G ;

Greiner, W ;

Grichine, V ;

Grossheim, A ;

Guatelli, S ;

Gumplinger, P ;

Hamatsu, R ;

Hashimoto, K ;

Hasui, H ;

Heikkinen, A ;

Howard, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303

[2] Electronic polarizability, dielectric, and gamma-ray shielding properties of some tellurite-based glasses [J].

Al-Buriahi, M. S. ;

Rammah, Y. S. .

APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2019, 125 (10)

[3] Investigation of photon energy absorption properties for some biomolecules [J].

Al-Buriahi, Mohammed Sultan ;

Arslan, Halil ;

Tonguc, Baris T. .

NUCLEAR SCIENCE AND TECHNIQUES, 2019, 30 (07)

[4] Comparison of Geant4 electromagnetic physics models against the NIST reference data [J].

Amako, K ;

Guatelli, S ;

Ivanchenko, VN ;

Maire, M ;

Mascialino, B ;

Murakami, K ;

Nieminen, P ;

Pandola, L ;

Parlati, S ;

Pia, MG ;

Piergentili, M ;

Sasaki, T ;

Urban, L .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2005, 52 (04) :910-918

[5] Investigation ofthe gamma ray shielding parameters of (100-x) [0.5Li2O-0.1B2O3-0.4P2O5]-xTeO2 glasses using Geant4 and FLUKA codes [J].

Askin, A. ;

Sayyed, M. I. ;

Sharma, Amandeep ;

Dal, M. ;

El-Mallawany, R. ;

Kacal, M. R. .

JOURNAL OF NON-CRYSTALLINE SOLIDS, 2019, 521

[6] Intravenous Contrast Medium Administration and Scan Timing at CT: Considerations and Approaches [J].

Bae, Kyongtae T. .

RADIOLOGY, 2010, 256 (01) :32-61

[7] Hafnium-Based Contrast Agents for X-ray Computed Tomography [J].

Berger, Markus ;

Bauser, Marcus ;

Frenzel, Thomas ;

Hilger, Christoph Stephan ;

Jost, Gregor ;

Lauria, Silvia ;

Morgenstern, Bernd ;

Neis, Christian ;

Pietsch, Hubertus ;

Suelzle, Detlev ;

Hegetschweiler, Kaspar .

INORGANIC CHEMISTRY, 2017, 56 (10) :5757-5761

[8] Implementation of new physics models for low energy electrons in liquid water in Geant4-DNA [J].

Bordage, M. C. ;

Bordes, J. ;

Edel, S. ;

Terrissol, M. ;

Franceries, X. ;

Bardies, M. ;

Lampe, N. ;

Incerti, S. .

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2016, 32 (12) :1833-1840

[9] Contrast agents in diagnostic imaging: Present and future [J].

Caschera, Luca ;

Lazzara, Angelo ;

Piergallini, Lorenzo ;

Ricci, Domenico ;

Tuscano, Bruno ;

Vanzulli, Angelo .

PHARMACOLOGICAL RESEARCH, 2016, 110 :65-75

[10] Influence of intravenous contrast agent on dose calculations of intensity modulated radiation therapy plans for head and neck cancer [J].

Choi, Youngmin ;

Kim, Jeung-Kee ;

Lee, Hyung-Sik ;

Hur, Won-Joo ;

Hong, Young-Seoub ;

Park, Sungkwang ;

Ahn, Kijung ;

Cho, Heunglae .

RADIOTHERAPY AND ONCOLOGY, 2006, 81 (02) :158-162

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