Markers of ventricular repolarization and overall mortality in sleep disordered breathing

被引:1
作者
Patel, Salma I. [1 ,2 ,10 ]
Zareba, Wojciech [3 ]
LaFleur, Bonnie [4 ,5 ,6 ]
Couderc, Jean-Phillipe [3 ]
Xia, Xiaojuan [3 ]
Woosley, Raymond [7 ]
Patel, Imran Y. [1 ,2 ]
Combs, Daniel [1 ,8 ]
Mashaqi, Saif [1 ,2 ]
Quan, Stuart F. [1 ,2 ,9 ]
Parthasarathy, Sairam [1 ,2 ]
机构
[1] Univ Arizona, UAHS Ctr Sleep & Circadian Sci, Tucson, AZ USA
[2] Univ Arizona Coll Med, Div Pulm Allergy Crit Care Med & Sleep Med, Tucson, AZ USA
[3] Univ Rochester, Clin Cardiovasc Res Ctr, Med Ctr, Rochester, NY USA
[4] Univ Arizona, UAHS Ctr Biomed Informat & Biostat, Tucson, AZ USA
[5] Univ Arizona, BIO5, Tucson, AZ USA
[6] Univ Arizona, R Ken Coit Coll Pharm, Tucson, AZ USA
[7] Univ Arizona Coll Med, Div Clin Data Analyt & Decis Support, Phoenix, AZ USA
[8] Univ Arizona Coll Med, Dept Pediat, Tucson, AZ USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Boston, MA USA
[10] Univ Med Ctr Sleep Disorders Ctr, Univ Arizona Coll Med Banner, MPH Div Pulm Allergy Crit Care & Sleep Med, POB 245040-A 1625 N,Campbell Ave,5030A, Tucson, AZ 85724 USA
基金
美国国家卫生研究院; 美国医疗保健研究与质量局;
关键词
Ventricular repolarization; QT interval; QT variability; Sleep disordered breathing; Sleep apnea; Mortality; QT INTERVAL VARIABILITY; DISTURBED CARDIAC REPOLARIZATION; ARTERIAL-HYPERTENSION; VARIABLE SELECTION; RISK-FACTOR; APNEA; ASSOCIATION; DURATION; DISEASE; ARRHYTHMIAS;
D O I
10.1016/j.sleep.2022.04.016
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Variability and prolongation of ventricular repolarization -measured by changes in QT interval and QT variability are independently associated with ventricular arrhythmias, sudden death, and mortality but such studies did not examine the role of sleep-disordered breathing. We aimed to determine whether sleep-disordered breathing moderated the association between measures of ventricular repolarization and overall mortality. Methods: Eight hundred participants were randomly selected from each of the following four groups in the Sleep Heart Health Study: mild, moderate, severe or no sleep disordered breathing (n = 200 each). Overnight electrocardiograms were analyzed for QTc duration and QT variability (standard deviation of QT intervals, normalized QT interval variance and the short-term interval beat-to-beat QT variability). Cox proportional hazards penalized regression modeling was used to identify predictors of mortality. Results: Eight hundred of 5600 participants were randomly selected. The participants (68 +/- 10 years; 56.8% male) were followed for an average of 8.2 years during which time 222 (28.4%) died. QTc, SDQT, and QTVN were associated with the presence of SDB (p = 0.002, p = 0.014, and p = 0.024, respectively). After adjusting for covariates, the presence of sleep-disordered breathing did not moderate the association between QTc length, QT variability and mortality (p > 0.05). Conclusion: Sleep-disordered breathing was associated with some measures of ventricular repolarization. However, sleep-disordered breathing was not an effect modifier for the relationship between QTc and QT variability and mortality. (C) 2022 Elsevier B.V. All rights reserved.
引用
收藏
页码:9 / 15
页数:7
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