Target cum Flexibility: Synthesis of Indolo[1,2-b]isoquinoline Derivatives via Cobalt-Catalyzed [2+2+2] Cyclotrimerization

被引：9

作者：

Swami, Anuradha ^{[1
]}

Ramana, Chepuri V. ^{[1
]}

机构：

[1] Natl Chem Lab, CSIR, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

SYNLETT | 2015年 / 26卷 / 05期

关键词：

2+2+2] cyclotrimerization; cobalt; indole; indolo[1,2-b]-isoquinoline; pyridine; NUCLEOPHILIC-SUBSTITUTION; PROTOBERBERINE ALKALOIDS; ACETYLENE CYCLIZATIONS; INDOLE ALKALOIDS; METAL; TETRAHYDROISOQUINOLINE; CYCLOADDITION; ACCESS; STRATEGY; ROUTE;

D O I：

10.1055/s-0034-1379950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modular approach for the synthesis of small molecules having the unnatural 6,11-dihydroindolo[1,2-b]isoquinoline tetracyclic core has been documented. An acid-catalyzed Friedel-Crafts-type C2-alkylation of N-propargyl indole with a suitably activated alkynol has been used to prepare the key indole-derived diynes. The cobalt-catalyzed [2+2+2] cyclotrimerization of these diynes has been studied with various internal/terminal alkynes and with nitriles.

引用

页码：604 / 608

页数：5

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