Epithelial differentiation in pancreatic development and neoplasia - New niches for nestin and notch

被引：27

作者：

Leach, SD ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21205 USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2005年 / 39卷 / 04期

关键词：

pancreas; embryo; stem cell; cancer; Ptfl;

D O I：

10.1097/01.mcg.0000155547.83901.a3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle,, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.

引用

页码：S78 / S82

页数：5

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