TFIIH: when transcription met DNA repair

被引：238

作者：

Compe, Emmanuel ^{[1
]}

Egly, Jean-Marc ^{[1
]}

机构：

[1] CNRS INSERM UdS, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 06期

基金：

欧洲研究理事会;

关键词：

RNA-POLYMERASE-II; NUCLEOTIDE EXCISION-REPAIR; CDK-ACTIVATING KINASE; CYCLIN-DEPENDENT KINASES; C-TERMINAL DOMAIN; XERODERMA-PIGMENTOSUM; GENERAL TRANSCRIPTION; DAMAGE RECOGNITION; NUCLEAR RECEPTORS; PROTEIN-KINASE;

D O I：

10.1038/nrm3350

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transcription initiation factor TFIIH is a remarkable protein complex that has a fundamental role in the transcription of protein-coding genes as well as during the DNA nucleotide excision repair pathway. The detailed understanding of how TFIIH functions to coordinate these two processes is also providing an explanation for the phenotypes observed in patients who bear mutations in some of the TFIIH subunits. In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'.

引用

页码：343 / 354

页数：12

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