Rational Design of a Tetrameric Protein to Enhance Interactions between Self-Assembled Fibers Gives Molecular Hydrogels

被引：116

作者：

Zhang, Xiaoli ^{[1
,2
]}

Chu, Xinlei ^{[1
,2
]}

Wang, Ling ^{[3
,4
]}

Wang, Huaimin ^{[1
,2
]}

Liang, Gaolin ^{[5
]}

Zhang, Jinxiu ^{[1
,2
]}

Long, Jiafu ^{[1
,2
]}

Yang, Zhimou ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

[3] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China

[4] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China

[5] Univ Sci & Technol China, Dept Chem, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 18期

关键词：

hydrogels; mechanical properties; protein-peptide interactions; proteins; self-assembly; PEPTIDE HYDROGEL; DRUG-DELIVERY; SUPRAMOLECULAR GELS; PHYSICAL HYDROGELS; ENCAPSULATION; PRODRUGS; GROWTH;

D O I：

10.1002/anie.201108612

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Styling gels: The fusion protein ULD-TIP-1 (ULD=ubiquitin-like domain, TIP-1=Tax-interacting protein-1) enhances the interactions between self-assembled fibers formed by small molecules bearing a peptide that specifically binds to the ULD-TIP-1. The mechanical properties of the resulting hydrogels (see picture) are tuned by using peptides with different dissociation constants for the protein. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4388 / 4392

页数：5

共 46 条

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