Reporter Gene Imaging of Immune Responses to Cancer: Progress and Challenges

被引：19

作者：

Dubey, Purnima ^{[1
,2
,3
]}

机构：

[1] Wake Forest Sch Med, Ctr Comprehens Canc, Dept Pathol Tumor Biol, Winston Salem, NC 27157 USA

[2] Wake Forest Sch Med, Ctr Comprehens Canc, Dept Canc Biol, Winston Salem, NC 27157 USA

[3] Wake Forest Sch Med, Ctr Comprehens Canc, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA

来源：

THERANOSTICS | 2012年 / 2卷 / 04期

关键词：

reporter gene imaging; immune responses; cancer; POSITRON-EMISSION-TOMOGRAPHY; GREEN FLUORESCENT PROTEIN; HUMAN T-LYMPHOCYTES; IN-VIVO; LENTIVIRAL VECTORS; PROSTATE-CANCER; LYMPHOID ORGANS; DENDRITIC CELLS; LIVING SUBJECTS; BIOLUMINESCENCE;

D O I：

10.7150/thno.3903

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Immune responses to cancer are dynamic processes which take place through the concerted activity of innate and adaptive cell populations. In order to fully understand the efficacy of immune therapies for cancer, it is critical to understand how the treatment modulates the function of each cell type involved in the anti-tumor immune response. Molecular imaging is a versatile method for longitudinal studies of cellular localization and function. The development of reporter genes for tracking cell movement and function was a powerful addition to the immunologist's toolbox. This review will highlight the advances and challenges in the use of reporter gene imaging to track immune cell localization and function in cancer.

引用

页码：355 / 362

页数：8

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