Semax Attenuates the Influence of Neonatal Maternal Deprivation on the Behavior of Adolescent White Rats

被引：0

作者：

Volodina, M. A. ^{[2
]}

Sebentsova, E. A. ^{[1
]}

Glazova, N. Y. ^{[1
]}

Levitskaya, N. G. ^{[1
]}

Andreeva, L. A. ^{[1
]}

Manchenko, D. M. ^{[2
]}

Kamensky, A. A. ^{[2
]}

Myasoedov, N. F. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Moscow 117234, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 152卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

maternal deprivation; Semax; body weight; anxiety; locomotor activity; ADULT RATS; STRESS; ANALOG; ACTH(4-10); DESIGN; MEMORY;

D O I：

10.1007/s10517-012-1574-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Maternal deprivation in the early postnatal period significantly affects the behavior and development of different animals. Here we studied delayed effects of daily maternal deprivation (5 h/day) on physical development and behavior of white rats during postnatal days 1 to 14. Here we studied the possibility of reducing the negative consequences of deprivation by daily intranasal treatment with Semax, an analog of ACTH(4-10), in a dose of 0.05 mg/kg from postnatal days 15 to 28. It was found that maternal deprivation decelerated the growth of young rats, boosted physical activity and emotional reactivity in novel environment, and increased anxiety in one-month-old animals. Semax weakened the impact of deprivation on animal body weight and normalized the levels of anxiety in rats.

引用

页码：560 / 563

页数：4

共 15 条

[1] Can adverse neonatal experiences alter brain development and subsequent behavior? [J].

Anand, KJS ;

Scalzo, FM .

BIOLOGY OF THE NEONATE, 2000, 77 (02) :69-82

[2]

Anand KJS, 2000, PROG BRAIN RES, V122, P117

[3]

ASHMARIN IP, 1995, NEUROSCI RES COMMUN, V16, P105

[4]

Ashmarin IP, 1997, ZH VYSSH NERV DEYAT+, V47, P420

[5] Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine [J].

Benetti, Fernando ;

Mello, Pamela Billig ;

Bonini, Juliana Sartori ;

Monteiro, Siomara ;

Cammarota, Martin ;

Izquierdo, Ivan .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2009, 27 (01) :59-64

[6] Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, daily maternal separation [J].

Cannizzaro, C ;

Plescia, F ;

Martire, M ;

Gagliano, M ;

Cannizzaro, G ;

Mantia, G ;

Cannizzaro, E .

BEHAVIOURAL BRAIN RESEARCH, 2006, 169 (01) :128-136

[7] Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus [J].

Dolotov, Oleg V. ;

Karpenko, Ekaterina A. ;

Inozemtseva, Lyudmila S. ;

Seredenina, Tamara S. ;

Levitskaya, Natalia G. ;

Rozyczka, Joanna ;

Dubynina, Elena V. ;

Nouosadova, Ekaterina V. ;

Andreeva, Lyudmila A. ;

Alfeeva, Lyudmila Yu. ;

Kamensky, Andrey A. ;

Grivennikov, Igor A. ;

Myasoedov, Nikolay F. ;

Engele, Jurgen .

BRAIN RESEARCH, 2006, 1117 :54-60

[8] Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences [J].

Hall, FS .

CRITICAL REVIEWS IN NEUROBIOLOGY, 1998, 12 (1-2) :129-162

[9] Functional correlates for 5-HT1A receptors in maternally deprived rats displaying anxiety and depression-like behaviors [J].

Lambas-Senas, Laura ;

Mnie-Filali, Ouissame ;

Certin, Veronique ;

Faure, Celine ;

Lemoine, Laetitia ;

Zimmer, Luc ;

Haddjeri, Nasser .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (02) :262-268

[10]

Levitskaya N. G., 2002, FIZIOL ZH, V88, P369

← 1 2 →