Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation

被引：169
|
作者：
Yasui, Yoshimmi [1 ]
Kamisaki, Haruhi [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 15期
关键词：
D O I：
10.1021/ol801168j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first enantioselective cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)(2), an optically active phosphoramidite, and N,N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions.
引用
收藏
页码：3303 / 3306
页数：4
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