Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells

被引:33
作者
Lin, Shu-Li [1 ]
Wang, Mei [2 ]
Cao, Qing-Qing [3 ]
Li, Qing [4 ]
机构
[1] Peoples Hosp Mengyin Cty, Dept Obstet & Gynecol, Linyi, Shandong, Peoples R China
[2] Peoples Hosp Boxing Cty, Dept Obstet & Gynecol, Binzhou, Shandong, Peoples R China
[3] Shandong Univ, Dept Nucl Med, Hosp 2, Jinan, Peoples R China
[4] Jinan Eighth Peoples Hosp, Dept Obstet & Gynecol, 73 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China
关键词
cervical cancer; chromatin modified protein 4C; EMT; proliferation; HUMAN-PAPILLOMAVIRUS; GLOBAL CANCER; EMT; PROGRESSION; PLASTICITY; CHECKPOINT; GENES; WOMEN;
D O I
10.1002/2211-5463.12880
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Despite improvements in prevention and treatment, cervical cancer (CC) still poses a serious threat to women's health. CHMP4C (chromatin modified protein 4C) is a subunit of the endosomal sorting complex required for transport, which is expressed in both nucleus and cytoplasm. Here, we examined the effect of CHMP4C on the biological behavior of CC cells and the underlying mechanisms. We report that CHMP4C expression is higher in CC tissues, and high CHMP4C expression is associated with lower survival. Up-regulation of CHMP4C in C-33A cells accelerates cell proliferation, migration and invasion, whereas down-regulation of CHMP4C in Ca Ski cells had the opposite effect. Moreover, overexpression of CHMP4C induced activation of the epithelial-mesenchymal transition pathway, whereas depletion of CHMP4C inhibited activation. Our results suggest that CHMP4C contributes to the viability and motility of CC cells by modulating epithelial-mesenchymal transition and may facilitate the identification of novel biomarkers for CC therapy.
引用
收藏
页码:1295 / 1303
页数:9
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