Stereochemistry .87. Synthesis of chiral non-racemic 2-arylpyrrolines by a [3+2] cycloaddition route

被引：31

作者：

Balasubramanian, T ^{[1
]}

Hassner, A ^{[1
]}

机构：

[1] BAR ILAN UNIV,DEPT CHEM,IL-52900 RAMAT GAN,ISRAEL

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/0040-4039(96)01176-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient diastereoselective (upto 76% de) synthesis of 2-aryl-3-pyrroline derivatives 3a-f has been achieved by [3+2] cycloaddition of allylsulfone 1 and non-racemic sulfinimines 2. Separation of the diastereomers led to optically pure 2(R)-pyrrolines (62-72% yield). The N-sulfinyl auxiliary can be removed with TFA. Copyright (C) 1996 Elsevier Science Ltd.

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页码：5755 / 5758

页数：4

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