Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke

被引：19
作者：
Kwak, Kyeong-Ah [1 ,2 ]
Kwon, Ho-Beom [2 ,3 ]
Lee, Joo Won [1 ,2 ]
Park, Young-Seok [1 ,2 ]
机构：
[1] Seoul Natl Univ, Dept Oral Anat, Sch Dent, 101 Daehakro, Seoul 03080, South Korea
[2] Dent Res Inst, 101 Daehakro, Seoul 03080, South Korea
[3] Seoul Natl Univ, Dept Prosthodont, Sch Dent, 101 Daehakro, Seoul 03080, South Korea
来源：
CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 28期
关键词：
Stroke; cell-based therapy; clinical trials; stem cells; angiogenesis; immunomodulation; ENDOTHELIAL PROGENITOR CELLS; MARROW MONONUCLEAR-CELLS; BONE-MARROW; MESENCHYMAL STEM; STROMAL CELLS; CEREBRAL-ISCHEMIA; UMBILICAL-CORD; SUBVENTRICULAR ZONE; FUNCTIONAL RECOVERY; IMPROVE RECOVERY;
D O I：
10.2174/1381612824666180604111806
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Stroke is a leading cause of death and disability worldwide. Conventional treatment has a limitation of very narrow therapeutic time window and its devastating nature necessitate a novel regenerative approach. Transplanted stem cells resulted in functional recovery through multiple mechanisms including neuroprotection, neurogenesis, angiogenesis, immunomodulation, and anti-inflammatory effects. Despite the promising features shown in experimental studies, results from clinical trials are inconclusive from the perspective of efficacy. The present review presents a synopsis of stem cell research on ischemic stroke treatment according to cell type. Clinical trials to the present are briefly summarized. Finally, the hurdles and issues to be solved are discussed for clinical application.
引用
收藏
页码：3332 / 3340
页数：9
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