Zwitterionic Polymers Coating Antibiofouling Photoelectrochemical Aptasensor for In Vivo Antibiotic Metabolism Monitoring and Tracking

被引：32

作者：

Lu, Shen ^{[1
]}

Fu, Baihe ^{[1
]}

Zhang, Zhonghai ^{[1
,2
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China

[2] East China Normal Univ, Inst Ecochongming, Shanghai 202162, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2022年

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.analchem.2c03465

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Long-term in vivo monitoring and tracking of target molecules in living organism is essential to reveal vital physiological activity. However, undesirable contamination of protein and biological cells may bring serious biofouling issues. Herein, zwitterionic sulfobetaine methacrylate (SBMA) polymers are grafted on the TiO2 nanotube (NT) surface with polydopamine (PDA) as linker to fabricate a TiO2 NTs/PDA/SBMA photoelectrode. The TiO2 NTs/PDA/SBMA/aptamer-based PEC aptasensor can be sensitive and have selective detection of target molecules with excellent antibiofouling activity. Beneficial from the above advantages, the implantable micro-PEC aptasensor has implemented in vivo tracking and monitoring of the metabolism of antibiotics in a living mouse. The robust antibiofouling property generates new inquiries and an approach for long-standing questions in a new way for reliable and long-term sensing of vital biomolecules in complex biological fluids and uncovers a promising advance of intrinsic physiological mechanisms.

引用

页码：14509 / 14516

页数：8